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ATP

Name: ATP
Brand: Selleck Chemicals
SKU: S5260
Rating: 5 (6 reviews)

Synonyms: Adenosine-Triphosphate, Adenosine 5'-triphosphate

Catalog No.S5260 Purity: 99.98%

ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.

ATP Chemical Structure

CAS: 56-65-5

Selleck's ATP has been cited by 6 publications

Purity & Quality Control

Batch: Purity: 99.98%

99.98

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Biological Activity

Description	ATP (Adenosine-Triphosphate, Adenosine 5'-triphosphate) is a multifunctional nucleoside triphosphate and an important endogenous signaling molecule in immunity and inflammation.

In vitro
In vitro	ATP, a multifunctional nucleoside triphosphate and an important endogenous signaling molecule, restores signaling responses to anti-TCR treatment in Jurkat cells.^[2]
Cell Research	Cell lines	Jurkat cells
	Concentrations	50 mM
	Incubation Time	--
	Method	Cells are washed with calcium-free and magnesium-free 1×DPBS to remove calcium and magnesium. Then cells are suspended with 450 µL 1×DPBS into a 1.5 mL centrifugal tube, treated with 50 mL Streptolysin O (0.5 µg/ml), and incubated 60 mins at 37℃. Next, cells are centrifuged at 400 g for 4 mins to discard the supernatant. Cells are re-suspended with 100 mL 1×DPBS, treated with 11 µL 50 mM ATP, and incubated in the 37℃ for indicated time.

In Vivo
In vivo	ATP can activate the NLRP3 inflammasome and enhance the production of pro-inflammatory cytokines, thus protecting mice against bacterial infection.^[3]
Animal Research	Animal Models	Kunming mice
	Dosages	50 mg/kg
	Administration	i.p.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT04760860	Not yet recruiting	Dementia With Lewy Bodies	Qiang Zhang\|University of Iowa	October 2024	Phase 1\|Phase 2
NCT05590195	Not yet recruiting	Bacterial Vaginosis\|Bacterial Infections\|Bacterial Vaginosis \| Vaginal \| Microbiology\|Vaginal Infection	Jeremy Burton\|Deerland Enzymes\|Lawson Health Research Institute\|St. Joseph''s Health Care London	May 1 2024	Phase 3
NCT06167512	Not yet recruiting	Multi-organ Failure After Severe Trauma	Assistance Publique - Hôpitaux de Paris	January 1 2024	--
NCT05938283	Not yet recruiting	Implantable Defibrillator User\|Hypertrophic Cardiomyopathy\|Implantable Cardioverter Ventricular Lead Dysfunction or Complication\|Ventricular Arrythmia	Barts & The London NHS Trust\|Boston Scientific Corporation\|Queen Mary University of London	January 1 2024	Not Applicable

References

Chemical lnformation & Solubility

Molecular Weight	507.18	Formula	C₁₀H₁₆N₅O₁₃P₃
CAS No.	56-65-5	SDF	--
Smiles	NC1=C2N=C[N](C3OC(CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)C(O)C3O)C2=NC=N1
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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