Home Neuronal Signaling Dopamine Receptor antagonist Azaperone For research use only.

Azaperone

Synonyms: NSC 170976

Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.

Azaperone Chemical Structure

Azaperone Chemical Structure

CAS: 1649-18-9

Selleck's Azaperone has been cited by 2 publications

Purity & Quality Control

Batch: S421901 DMSO] 65 mg/mL] false] Ethanol] 34 mg/mL] false] Water] Insoluble] false Purity: 99.93%
99.93

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Biological Activity

Description Azaperone (NSC 170976) crosses the blood-brain barrier and binds to both DI and D2 receptors, being an antagonist of Dopamine receptors with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.
Targets
Dopamine receptor [6]
In Vivo
In vivo

Azaperone eliminates fighting only for a few hours after it is administered, after which the behaviour of pigs treated with it is not different from that of non-tranquillized mixed pigs. [1] Azaperone (2.2 mg/kg i.m.) reduces total fighting from 309.8 min for saline to 189.6 min in pigs. [2] Azaperone (103.1 mg) combined with Butorphanol (69.3 mg) produces adequate muscle relaxation and apparently adequate analgesia for minor surgical interferences, including abdominal laparoscopy, in a white rhinoceros with chronic renal disease. [3] Azaperone combined with Butorphanol and Medetomidine (BAM: 0.43 mg/kg Butorphanol, 0.36 mg/kg Azaperone, 0.14 mg/kg Medetomidine) results in a predictable onset of sedation, with a mean induction time to lateral recumbency of 9.8 min, in white-tailed deer. Azaperone combined with Butorphanol and Medetomidine (BAM: 0.43 mg/kg Butorphanol, 0.36 mg/kg Azaperone, 0.14 mg/kg Medetomidine) results in decreased heart rate and increased arterial partial pressure of carbon dioxide (PaCO2) in white-tailed deer. [4] Azaperone (1.0 mg/kg) combined with Ketamine (15 mg/kg) and Climazolam (1.5 mg/kg) results in a significantly higher castration score, when administrated intranasally (IN) compared with intramuscularly (IM) in piglets, there is an association between castration score and room temperature in the IN group. Azaperone (1.0 mg/kg) combined with Ketamine (15 mg/kg) and Climazolam (1.5 mg/kg) results in higher heart rate in the IN group of piglets. Azaperone (1.0 mg/kg) combined with Ketamine (15 mg/kg) and Climazolam (1.5 mg/kg) results in higher respiratory rate and walking significantly faster in the IM group of piglets. [5]

Chemical lnformation & Solubility

Molecular Weight 327.4 Formula

C19H22FN3O
CAS No. 1649-18-9 SDF Download Azaperone SDF
Smiles C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=CC=CC=N3
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 65 mg/mL ( (198.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 34 mg/mL

Water : Insoluble


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In vivo
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