Home Neuronal Signaling Dopamine Receptor antagonist Penfluridol For research use only.

Penfluridol

Synonyms: TLP-607,R-16341

Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.

Penfluridol Chemical Structure

Penfluridol Chemical Structure

CAS: 26864-56-2

Selleck's Penfluridol has been cited by 3 publications

Purity & Quality Control

Batch: Purity: >97%
97

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Biological Activity

Description Penfluridol (TLP-607,R-16341) is a highly potent, first generation diphenylbutylpiperidine antipsychotic.
Targets
Dopamine receptor [1]
(Cell-free assay)
1.6 μM(Ki)
In vitro
In vitro

Penfluridol is a neuroleptic drug with long duration of action, which is able to relieve both negative and positive symptoms of schizophrenia. Penfluridol inhibits the binding of dopamine to dopamine receptor with Ki of 1.6 μM. It exerts its antipsychotic activity by blocking the dopamine projections in the limbic system and in mesocortical area. [1] Penfluridol selectively inhibits the binding of [3H]nitrendipine to rat cerebral cortical membrane fraction and also competitively antagonizes potassium-induced calcium-dependent contractions in rat vas deferens. Penfluridol (10 μM) inhibits the contractile response of isolated rings of rabbit thoracic aorta to NE and KCl, and inhibits calcium influx during either NE or KCl stimulation. [2]

Chemical lnformation & Solubility

Molecular Weight 523.97 Formula

C28H27ClF5NO
CAS No. 26864-56-2 SDF Download Penfluridol SDF
Smiles C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (190.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble


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In vivo
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Tech Support

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