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Calcipotriene (MC903)

Name: Calcipotriene (MC903)
Brand: Selleck Chemicals
SKU: S3739
Rating: 5 (5 reviews)

Synonyms: Calcipotriol

Catalog No.S3739 Purity: 97%

Calcipotriene (MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

Calcipotriene (MC903) Chemical Structure

CAS: 112965-21-6

Selleck's Calcipotriene (MC903) has been cited by 5 publications

Purity & Quality Control

Batch: Purity: >97%

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Biological Activity

Description	Calcipotriene (MC903) is a synthetic derivative of calcitriol, a form of vitamin D. It can induce differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and lead to normalization of epidermal growth. Calcipotriol is a synthetic VitD3 analogue with a high affinity for the vitamin D receptor.

In vitro
In vitro	Calcipotriene enhances IL-10 secretion in psoriatic skin and in human T cells, induces secretion of type 2 cytokines by T cells and, significantly modulates the differentiation of DCs and T cells^[1].
Cell Research	Cell lines	Monocytes (CD14+ cells)-derived DCs
	Concentrations	100 nM
	Incubation Time	24 h or 3 days
	Method	Cells are treated in duplicates with 100 nM calcipotriol, 1 mM betamethasone (BDP), combination of calcipotriol and betamethasone (100 nM/1 mM; ratio 1:10 as in the fixed-combination product) or a corresponding vehicle control (0.1% DMSO). Treatment is applied after the first 5 days in culture and before and throughout the 3 days of activation with LPS and IFN-γ or two days after activation with LPS and IFN-γ and throughout the last 24 h of activation.

In Vivo
In vivo	Calcipotriol suppresses skin cancer development in mice in a TSLP-dependent manner. Calcipotriol is a well-tolerated topical medication for psoriasis. The low concentration of calcipotriol in the clinically available formulation (0.005% ointment) dampens its effect against skin cancer development in mice^[2].
Animal Research	Animal Models	genetically engineered mouse models
	Dosages	80 nM
	Administration	topical

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT05954104	Completed	Alopecia Areata	Egymedicalpedia	July 1 2023	Not Applicable
NCT03596073	Recruiting	Breast Cancer	Massachusetts General Hospital	November 7 2018	Phase 1
NCT03476746	Completed	Healthy	LEO Pharma	March 20 2018	Phase 1
NCT03462927	Completed	Psoriasis Vulgaris	MC2 Therapeutics	February 8 2018	Phase 2

References

Chemical lnformation & Solubility

Molecular Weight	412.60	Formula	C₂₇H₄₀O₃
CAS No.	112965-21-6	SDF	Download Calcipotriene (MC903) SDF
Smiles	CC(C=CC(C1CC1)O)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 83 mg/mL ( (201.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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