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Choline Fenofibrate

Name: Choline Fenofibrate
Brand: Selleck Chemicals
SKU: S5812

Synonyms: ABT-335

Catalog No.S5812 Purity: 99.97%

Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.

Choline Fenofibrate Chemical Structure

CAS: 856676-23-8

Purity & Quality Control

Batch: S581201 Water] 9 mg/mL] false] Ethanol] 7 mg/mL] false] DMSO] 5 mg/mL] false Purity: 99.97%

99.97

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Biological Activity

Description	Choline fenofibrate(ABT-335) is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist.

In vitro
In vitro	WAY-316606 enhances hair shaft production, hair shaft keratin expression, and inhibits spontaneous HF regression (catagen) ex vivo. WAY-316606 effectively enhances β-catenin activity in mammalian skin cell populations, namely in both human hair pre-cortex keratinocytes and DP fibroblasts ex vivo^[1].

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT00839293	Completed	Healthy	Abbott	February 2009	Phase 1
NCT00808678	Completed	Healthy	AstraZeneca	December 2008	Phase 1
NCT00826358	Completed	Healthy	AstraZeneca	November 2008	Phase 1
NCT00585143	Completed	Dyslipidemia Renal Insufficiency	AstraZeneca	January 2008	Phase 1

References

[1] Nathan J. Hawkshaw, et al. PLoS Biol. 2018, 16(5): e2003705.

Chemical lnformation & Solubility

Molecular Weight	421.91	Formula	C₂₂H₂₈ClNO₅
CAS No.	856676-23-8	SDF	--
Smiles	CC(C)(C(=O)[O-])OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl.C[N+](C)(C)CCO
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 9 mg/mL

Ethanol : 7 mg/mL

DMSO : 5 mg/mL ( (11.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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