Home Transmembrane Transporters Calcium Channel agonist Cinacalcet For research use only.

Cinacalcet

Synonyms: AMG073, Sensipar, Cin

Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.

Cinacalcet Chemical Structure

Cinacalcet Chemical Structure

CAS: 226256-56-0

Selleck's Cinacalcet has been cited by 1 publication

Purity & Quality Control

Batch: S519101 Purity: 99.98%
99.98

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Biological Activity

Description Cinacalcet (AMG073, Sensipar, Cin) is an orally active, allosteric agonist of receptors for calcium (CaR) that increases the sensitivity of the CaR to Ca.
Targets
CaR [1]
In vitro
In vitro

Cinacalcet can activate CaSR and elicit an increase of atg7, becn and lc3a mRNA transcripts.[2]
Cell Research Cell lines human AT-derived (primary) preadipocytes
Concentrations 2 μM
Incubation Time 6 h
Method

Isolation of human AT-derived (primary) preadipocytes was performed. After passage 3 in culture with DMEM:F12 and 10% FBS, preadipocytes were switched to 2.5% FBS and exposed to cinacalcet, spermine and/or the upstream ERK (MAPK) inhibitor U0126, plus the autophagy flux inhibitor CQ for the last 2-3 h. CaSR activators were used for 6 h, while U0126 was used 1 h before exposure to the CaSR activator.

(Data sourced from selleck products)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06144229 Not yet recruiting Hiv|Hpv University of California Los Angeles|Harvard School of Public Health (HSPH)|Frontier Science & Technology Research Foundation Inc.|Albert Einstein College of Medicine|Boston Children''s Hospital|St. Jude Children''s Research Hospital|University of Colorado Denver|Bronx-Lebanon Hospital Center Health Care System|University of Miami|Baylor College of Medicine|Children''s Hospital New Orleans LA|Jacobi Medical Center|Ann & Robert H Lurie Children''s Hospital of Chicago|Westat April 2024 --
NCT05906758 Not yet recruiting Acute Kidney Injury Tulane University March 2024 Phase 3
NCT06153849 Not yet recruiting Bladder Cancer Changhai Hospital December 1 2023 --
NCT06052696 Not yet recruiting Vulvar HSIL|HPV Erasmus Medical Center|Dutch Cancer Society December 1 2023 Phase 4
NCT06188104 Withdrawn CIN1|Trichloroacetic Acid Rajavithi Hospital November 30 2023 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 357.41 Formula

C22H22F3N
CAS No. 226256-56-0 SDF --
Smiles CC(NCCCC1=CC(=CC=C1)C(F)(F)F)C2=CC=CC3=CC=CC=C23
Storage (From the date of receipt) 2 years -20°C liquid

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