Home Transmembrane Transporters Calcium Channel inhibitor Cinepazide maleate For research use only.

Cinepazide maleate

Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.

Cinepazide maleate Chemical Structure

Cinepazide maleate Chemical Structure

CAS: 26328-04-1

Purity & Quality Control

Batch: S304501 DMSO] 107 mg/mL] false] Water] 107 mg/mL] false] Ethanol] Insoluble] false Purity: 99.82%
99.82

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Biological Activity

Description Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator.
Targets
Calcium channel [1]
In Vivo
In vivo Cinepazide (3 mg/kg -30 mg/kg, i.v.) produces a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide exerts positive inotropic and chronotropic actions. Cinepazide (30 mg/kg, i.v.) potentiates the vertebral vasodilator response of dogs to intravertebral adenosine and cyclic AMP. Intravertebral cinepazide (1 mg -10 mg) increases vertebral blood flow in a dose-related manner and the effect is partially inhibited by intravenous pretreatment with aminophylline but not by pretreatment with autonomic antagonists. [1] Cinepazide is well absorbed and more than 60% of the dose is excreted within 24 hours. In 5 days, rats, dogs, and man excretes in the urine and faeces respectively 36.7% and 58.3%, 33.4% and 68.6%, and 61.3% and 38.1% dose. [2] Cinepazide at doses of 1 mg/kg - 3 mg/kg i.v. decreases systemic blood pressure by 4% and reflexly increases heart rate by 8%. [3] Cinepazide selectively stimulates the functional activities of 5-HT neurons in the brain, which are depressed by hypoxia. [4]
Animal Research Animal Models Male Wistar rats weighing 170 g -200 g
Dosages 4 mg/kg, 20 mg/kg, 100 mg/kg and 150 mg/kg
Administration i.p.

Chemical lnformation & Solubility

Molecular Weight 533.57 Formula

C22H31N3O5.C4H4O4
CAS No. 26328-04-1 SDF Download Cinepazide maleate SDF
Smiles COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCN(CC2)CC(=O)N3CCCC3.C(=CC(=O)O)C(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 107 mg/mL ( (200.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 107 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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