Home Endocrinology & Hormones Androgen Receptor antagonist Clascoterone For research use only.

Clascoterone

Synonyms: Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01

Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR).

Clascoterone Chemical Structure

Clascoterone Chemical Structure

CAS: 19608-29-8

Purity & Quality Control

Batch: S689601 DMSO] 80 mg/mL] false] Ethanol] 80 mg/mL] false] Water] Insoluble] false Purity: 99.07%
99.07

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Biological Activity

Description Clascoterone (Winlevi, Cortexolone 17 alpha-propionate, Cortexolone 17α-propionate, CB-03-01) is a topical and peripherally selective antagonist of androgen receptor (AR).
Targets
AR [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03665194 Completed Healthy Volunteers Cassiopea SpA June 6 2018 Phase 1
NCT01831960 Completed Acne Vulgaris Intrepid Therapeutics Inc. April 2013 Phase 2

Chemical lnformation & Solubility

Molecular Weight 402.52 Formula

C24H34O5
CAS No. 19608-29-8 SDF --
Smiles CCC(=O)OC1(CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C)C(=O)CO
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 80 mg/mL ( (198.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 80 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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