Home Transmembrane Transporters Calcium Channel inhibitor Dantrolene sodium hemiheptahydrate For research use only.

Dantrolene sodium hemiheptahydrate

Synonyms: Dantrolene sodium salt, Dantrium, Sodium dantrolene

Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.

Dantrolene sodium hemiheptahydrate Chemical Structure

Dantrolene sodium hemiheptahydrate Chemical Structure

CAS: 24868-20-0

Selleck's Dantrolene sodium hemiheptahydrate has been cited by 2 publications

Purity & Quality Control

Batch: S464801 DMSO] 14 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.33%
99.33

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Biological Activity

Description Dantrolene sodium hemiheptahydrate (Dantrium) is a skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber.
In vitro
In vitro Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. Dantrolene sodium shows strong antioxidant activity in the linoleic acid emulsion system[2].
In Vivo
In vivo Dantrolene sodium (5 mg/kg) has a greater depressant action on the twitch contraction of the fast extensor digitorum longus (EDL) muscle than on the slow soleus (SOL) muscle[1].
Animal Research Animal Models Sprague Dawley rats
Dosages 5 mg/kg
Administration i.v.

Chemical lnformation & Solubility

Molecular Weight 399.29 Formula

C14H9N4O5.7/2H2O.Na
CAS No. 24868-20-0 SDF Download Dantrolene sodium hemiheptahydrate SDF
Smiles C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].C1C(=NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-])[O-].O.O.O.O.O.O.O.[Na+].[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 14 mg/mL ( (35.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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