Home Microbiology Parasite inhibitor Decoquinate For research use only.

Decoquinate

Decoquinate is a coccidiostat.

Decoquinate Chemical Structure

Decoquinate Chemical Structure

CAS: 18507-89-6

Purity & Quality Control

Batch: S414501 4-Methylpyridine] 5 mg/mL] true] DMSO] 0.01 mg/mL] false] Water] Insoluble] false Purity: 98.53%
98.53

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Biological Activity

Description Decoquinate is a coccidiostat.
In vitro
In vitro Decoquinate is a feed additive intended for the control of coccidiosis, a debilitating protozoal infection in poultry. The active agent is 4-hydroxyquinoline, incorporated at 0.6 % by weight in the feed additive. Evidence generated at the time of its introduction suggests that a product delivering 20-40 mg of decoquinate per kg complete feed is effective as a coccidiostat for chickens. Decoquinate plays a role in the asexual propagation of coccidium. It will stop the growth of ascospore by disturbing the DNA synthesis. Decoquinate acts on the early living period of coccidium, so it can prevent the harm of the fowl's intestinal wall. [1]
In Vivo
In vivo Decoquinate Premix can be absorbed fastly. It can reach the virtual concentration within 1 hour, and reach the highest concentration after 3 days. The NOEL of 15 mg/kg bw/day may be used as the basis for setting an acceptable daily intake (ADI) for decoquinate. [1]

Chemical lnformation & Solubility

Molecular Weight 417.54 Formula

C24H35NO5
CAS No. 18507-89-6 SDF Download Decoquinate SDF
Smiles CCCCCCCCCCOC1=C(C=C2C(=C1)C(=O)C(=CN2)C(=O)OCC)OCC
Storage (From the date of receipt)

In vitro
Batch:

4-Methylpyridine : 5 mg/mL

DMSO : 0.01 mg/mL ( (0.02 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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