Home Microbiology Reverse Transcriptase inhibitor Delavirdine mesylate For research use only.

Delavirdine mesylate

Synonyms: U 90152 mesylate

Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.

Delavirdine mesylate Chemical Structure

Delavirdine mesylate Chemical Structure

CAS: 147221-93-0

Selleck's Delavirdine mesylate has been cited by 1 publication

Purity & Quality Control

Batch: S645201 DMSO] 100 mg/mL] false] Ethanol] 4 mg/mL] false] Water] Insoluble] false Purity: 99.84%
99.84

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Biological Activity

Description Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor.
Targets
HIV1 RT [1]
0.26 μM
In vitro
In vitro

Delavirdine is a potent and selective inhibitor of the HIV-1 RT (IC50=0.26 μM verus IC50s>440 μM for pol alpha and delta). Delavirdine has low cellular cytotoxicity, causing less than 8% reduction in human lymphocyte viability at 100 μM[1].
In Vivo
In vivo

Following single dose administration, the pharmacokinetics of delavirdine is nonlinear in rats, and appeared to be nonlinear in dogs. Systemic clearances in the dog, at a dose of 10 mg/kg, are approximately 20-fold lower than in the rat, whereas the clearances in monkeys are comparable to those in rats. Absolute p.o. bioavailabilities increase in the order monkey (30%) < rat (65%) < dog (100%) when equivalent i.v. and p.o. doses are administered[1].

Chemical lnformation & Solubility

Molecular Weight 552.67 Formula

C23H32N6O6S2
CAS No. 147221-93-0 SDF --
Smiles CC(C)NC1=C(N=CC=C1)N2CCN(CC2)C(=O)C3=CC4=C(N3)C=CC(=C4)NS(=O)(=O)C.CS(=O)(=O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (180.93 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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