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Doripenem

Name: Doripenem
Brand: Selleck Chemicals
SKU: S5531
Rating: 5 (2 reviews)

Synonyms: S 4661

Catalog No.S5531 Purity: 98%

Doripenem(S 4661) is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

Doripenem Chemical Structure

CAS: 148016-81-3

Selleck's Doripenem has been cited by 2 publications

Purity & Quality Control

Batch: S553101 DMSO] 60 mg/mL] false] ] ] false] ] ] false Purity: 98%

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Biological Activity

Description	Doripenem(S 4661) is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01366651	Terminated	Meningitis	Janssen Research & Development LLC	March 2012	Phase 1
NCT01524302	Completed	Pneumonia Bacterial\|Community-acquired	Gary E. Stein Pharm.D.\|Forest Laboratories\|Michigan State University	February 2012	Phase 4
NCT01467648	Completed	Ventilator-Associated Pneumonia	Sutep Jaruratanasirikul\|Prince of Songkla University	October 2010	Phase 4
NCT01401010	Completed	Febrile Neutropenia	Gary E. Stein Pharm.D.\|Michigan State University	August 2010	Phase 4

Chemical lnformation & Solubility

Molecular Weight	420.50	Formula	C₁₅H₂₄N₄O₆S₂
CAS No.	148016-81-3	SDF	--
Smiles	CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 60 mg/mL ( (142.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

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In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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