Home DNA Damage/DNA Repair Topoisomerase inhibitor Doxorubicin For research use only.

Doxorubicin

Synonyms: Adriamycin,Hydroxydaunorubicin

Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM.

Doxorubicin Chemical Structure

Doxorubicin Chemical Structure

CAS: 23214-92-8

Selleck's Doxorubicin has been cited by 75 publications

Purity & Quality Control

Batch: Purity: 99.71%
99.71

Products often used together with Doxorubicin

Paclitaxel

Doxorubicin and Paclitaxel use exhibit more significant tumor regression in vivo.

Jin C, et al. J Cancer Res Clin Oncol. 2010 Feb;136(2):267-74.

MK-2206 2HCl

Doxorubicin and MK-2206 2HCl exert a profound inhibitory effect on MMP-2 and MMP-9 expression in H929 cells.

Yang YL, et al. Zhongguo shi yan xue ye xue za zhi 30.2 (2022): 487-492

Cisplatin

Doxorubicin and Cisplatin are two commonly co-administered chemotherapy drugs used to treat a wide range of cancers.

Lopes F, et al. Reproduction. 2020 Feb; 159(2): 193–204.

Bortezomib

Doxorubicin and Bortezomib combination use enhances apoptotic activity and suppresses anti-apoptotic pathways in various tumour model systems.

Plosker GL, Drugs 68 (2008): 2535-2551.

Cyclophosphamide

Doxorubicin and Cyclophosphamide therapy suppress tumor growth in both tumor-specific and T-cell-dependent manners.

Tongu M, et al. Cancer Immunol Immunother. 2010 May;59(5):769-77.

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Biological Activity

Description Adriamycin (Doxorubicin, Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent, inhibits topoisomerase II with an IC50 of 2.67 μM, thus stopping DNA replication, and induces apoptosis, also inhibits human DNA topoisomerase I with an IC50 of 0.8 μM.
Targets
topoisomerase I [3]
(in assay of DNA Topo I activity)		 topoisomerase II [1]
(in decatenation assay for topoisomerase II activity)
0.8 μM 2.67 μM

Chemical lnformation & Solubility

Molecular Weight 543.52 Formula

C27H29NO11
CAS No. 23214-92-8 SDF --
Smiles COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (183.98 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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