Home Cytoskeletal Signaling Microtubule Associated inhibitor Eribulin Mesylate For research use only.

Eribulin Mesylate

Synonyms: B-1939 mesylate, ER-086526 mesylate,E7389 mesylate

Eribulin Mesylate, an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.

Eribulin Mesylate Chemical Structure

Eribulin Mesylate Chemical Structure

CAS: 441045-17-6

Purity & Quality Control

Batch: S891201 DMSO] 100 mg/mL] false] Ethanol] 100 mg/mL] false] ] ] false Purity: 99.77%
99.77

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Biological Activity

Description Eribulin Mesylate, an analogue of the marine natural product halichondrin B, is a nontaxane completely synthetic microtubule inhibitor.
Targets
microtubule [1]
In vitro
In vitro

Eribulin Mesylate (1-100 nM; 72 h) inhibits cells proliferation of LM8 and Dunn cells. Eribulin Mesylate (10-50 nM; 12-72 h) increases early apoptosis significantly in LM8 cells. Eribulin Mesylate (10-50 nM; 12-72 h) induces G2/M arrest by 12 h treatment with at the dose of 50 nM, but not by long-term treatment (72 h) with 10 nM in LM8 cells. Eribulin Mesylate (1-10 nM; 16 h) induces morphological change and suppresses cell migration in a low concentration in LM8 cells.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Cell Research Cell lines LM8 cells, Dunn cells
Concentrations 10 nM, 50 nM
Incubation Time 72 h
Method

LM8 cells and  Dunn cells are incubated with 0 nM, 10 nM, or 50 nM eribulin Mesylate for 12 h, 24 h, 48 h, or 72 h. And then cell proliferation, cell cycle and apoptosis are detected by flow cytometry analysis and immunofluorescence.
In Vivo
In vivo

Eribulin Mesylate reduces primary tumor growth and lung metastasis of osteosarcoma in mice.<sup><a class="sref" href="#s_ref">[2]</a></sup>
Animal Research Animal Models 4-week-old C3H/HeN mice inoculated with LM8 cells
Dosages 1 mg/kg
Administration I.v.

Chemical lnformation & Solubility

Molecular Weight 826 Formula

C41H63NO14S
CAS No. 441045-17-6 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (121.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL


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In vivo
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