Home Neuronal Signaling AChR antagonist Glycopyrrolate For research use only.

Glycopyrrolate

Synonyms: Glycopyrrolate bromide, Glycopyrronium bromide, Robinul, Gastrodyn

Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.

Glycopyrrolate Chemical Structure

Glycopyrrolate Chemical Structure

CAS: 596-51-0

Selleck's Glycopyrrolate has been cited by 1 publication

Purity & Quality Control

Batch: S466001 Water] 79 mg/mL] false] DMSO] 65 mg/mL] false] Ethanol] 59 mg/mL] false Purity: 99.91%
99.91

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Biological Activity

Description Glycopyrrolate (Glycopyrronium, Robinul, Gastrodyn) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.
Targets
Muscarinic receptor [1]
In vitro
In vitro Glycopyrrolate inhibits EFS-induced contraction of guinea-pig trachea and human airways in a concentration-dependent manner. In competition studies, glycopyrrolate binds human peripheral lung and human airway smooth muscle (HASM) muscarinic receptors with affinities in the nanomolar range (Ki values 0.5–3.6 nM). Glycopyrrolate showed no selectivity in its binding to the M1–M3 receptors. Kinetics studies show that glycopyrrolate dissociates slowly from HASM muscarinic receptors[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04979039 Unknown status Cesarean Section Seoul National University Bundang Hospital August 1 2021 --
NCT04554589 Unknown status Effect of Drugs Tanta University September 14 2020 Phase 1

Chemical lnformation & Solubility

Molecular Weight 398.33 Formula

C19H28NO3.Br
CAS No. 596-51-0 SDF Download Glycopyrrolate SDF
Smiles C[N+]1(CCC(C1)OC(=O)C(C2CCCC2)(C3=CC=CC=C3)O)C.[Br-]
Storage (From the date of receipt)

In vitro
Batch:

Water : 79 mg/mL

DMSO : 65 mg/mL ( (163.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 59 mg/mL


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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