Home Transmembrane Transporters Potassium Channel activator Hexachlorophene For research use only.

Hexachlorophene

Synonyms: Hexachlorofen, Fostril, Nabac, pHisoHex

Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Hexachlorophene Chemical Structure

Hexachlorophene Chemical Structure

CAS: 70-30-4

Selleck's Hexachlorophene has been cited by 2 publications

Purity & Quality Control

Batch: S463201 DMSO] 81 mg/mL] false] Ethanol] 81 mg/mL] false] Water] Insoluble] false Purity: 99.35%
99.35

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Biological Activity

Description Hexachlorophene (Hexachlorofen, Fostril, Nabac, pHisoHex) is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 μM; It can also attenuate Wnt/beta-catenin signaling through the Siah-1-mediated beta-catenin degradation.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
KCNQ1/KCNE1 [1]
(CHO cells)
4.61 μM(EC50)
In vitro
In vitro Hexachlorophene, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. HCP potently increases the current amplitude of KCNQ1/KCNE1 expressed by stabilizing the channel in an open state with an EC50 of 4.61±1.29 μM. HCP significantly shortens the action potential duration at 1 μM in cardiomyocytes. In addition, HCP is capable of rescuing the loss of function of the LQTs mutants caused by either impaired activation gating or phosphatidylinositol-4,5-bisphosphate (PIP2) binding affinity[1].

Chemical lnformation & Solubility

Molecular Weight 406.90 Formula

C13H6Cl6O2
CAS No. 70-30-4 SDF Download Hexachlorophene SDF
Smiles C1=C(C(=C(C(=C1Cl)Cl)CC2=C(C(=CC(=C2Cl)Cl)Cl)O)O)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 81 mg/mL ( (199.06 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 81 mg/mL

Water : Insoluble


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In vivo
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