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Ibutilide Fumarate

Name: Ibutilide Fumarate
Brand: Selleck Chemicals
SKU: S2118
Rating: 5 (2 reviews)

Synonyms: U-70226E,Corvert Fumarate

Catalog No.S2118 Purity: 99.97%

Ibutilide Fumarate (U-70226E,Corvert Fumarate) is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.

Ibutilide Fumarate Chemical Structure

CAS: 122647-32-9

Selleck's Ibutilide Fumarate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.97%

99.97

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Biological Activity

Description

Targets

Sodium channel ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03834883	Recruiting	Long QT Syndrome\|Abnormalities Drug-Induced	Indiana University\|American Heart Association\|Purdue University	March 26 2019	Phase 4
NCT01929083	Completed	Prolonged QT Interval in EKG and Sudden Death	Indiana University\|American Heart Association	April 2013	Phase 2
NCT00589992	Unknown status	Atrial Fibrillation\|Pulmonary Vein Ablation	Ball Memorial Hospital\|Abbott Medical Devices	October 2007	Not Applicable

Chemical lnformation & Solubility

Molecular Weight	885.23	Formula	(C₂₀H₃₆N₂O₃S)₂.C₄H₄O₄
CAS No.	122647-32-9	SDF	Download Ibutilide Fumarate SDF
Smiles	CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.CCCCCCCN(CC)CCCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.C(=CC(=O)O)C(=O)O
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 89 mg/mL ( (100.53 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 89 mg/mL

Ethanol : 89 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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