Home Immunology & Inflammation Bacterial inhibitor - Antibiotics inhibitor - Antineoplastic and Immunosuppressive Antibiotics chemical Lefamulin acetate (Xenleta) For research use only.

Lefamulin acetate (Xenleta)

Synonyms: BC-3781 acetate

Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.

Lefamulin acetate (Xenleta) Chemical Structure

Lefamulin acetate (Xenleta) Chemical Structure

CAS: 1350636-82-6

Selleck's Lefamulin acetate (Xenleta) has been cited by 1 publication

Purity & Quality Control

Batch: S349601 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 100 mg/mL] false Purity: 98.98%
98.98

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Biological Activity

Description Lefamulin acetate (Xenleta, BC-3781 acetate) is a pleuromutilin antibiotic for community-acquired bacterial pneumonia (CABP) treatment. Lefamulin acetate inhibits protein synthesis by binding to the peptidyl transferase center of the 50S bacterial ribosome, thus preventing the binding of transfer RNA for peptide transfer.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05111002 Terminated Mycoplasma Genitalium Infection University of Washington|Nabriva Therapeutics AG April 22 2022 Phase 1|Phase 2
NCT05225805 Completed Cystic Fibrosis Nabriva Therapeutics AG March 1 2022 Phase 1
NCT03131141 Completed Healthy Nabriva Therapeutics AG|Quotient Clinical January 8 2017 Phase 1
NCT02557789 Completed Healthy Nabriva Therapeutics AG June 2015 Phase 1

Chemical lnformation & Solubility

Molecular Weight 567.78 Formula

C30H49NO7S
CAS No. 1350636-82-6 SDF --
Smiles CC1CCC23CCC(=O)C2C1(C)C(CC(C)(C=C)C(O)C3C)OC(=O)CSC4CCC(N)CC4O.CC(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (176.12 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL


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In vivo
Batch:

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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