Home Neuronal Signaling Adrenergic Receptor agonist Medetomidine HCl For research use only.

Medetomidine HCl

Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

Medetomidine HCl Chemical Structure

Medetomidine HCl Chemical Structure

CAS: 86347-15-1

Selleck's Medetomidine HCl has been cited by 1 publication

Purity & Quality Control

Batch: S306001 Water] 47 mg/mL] false] Ethanol] 47 mg/mL] false] DMSO] 12 mg/mL] false Purity: 99.92%
99.92

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Biological Activity

Description Medetomidine is a selective α2-adrenoceptor agonist, with Ki of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.
Targets
α2-adrenoceptor [1]
1.08 nM(Ki)
In vitro
In vitro Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors. [1]
In Vivo
In vivo In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. [2] Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover. [3]
Animal Research Animal Models Rat
Dosages 1-100 μg/kg
Administration i.v.

Chemical lnformation & Solubility

Molecular Weight 236.74 Formula

C13H16N2.HCl
CAS No. 86347-15-1 SDF Download Medetomidine HCl SDF
Smiles CC1=C(C(=CC=C1)C(C)C2=CN=CN2)C.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 47 mg/mL

Ethanol : 47 mg/mL

DMSO : 12 mg/mL ( (50.68 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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