Home Cytoskeletal Signaling Microtubule Associated inhibitor - ADC Cytotoxin chemical DM1 (Mertansine) For research use only.

DM1 (Mertansine)

Synonyms: Maytansinoid DM1

DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.

DM1 (Mertansine) Chemical Structure

DM1 (Mertansine) Chemical Structure

CAS: 139504-50-0

Purity & Quality Control

Batch: S677301 DMSO] 50 mg/mL] false] Ethanol] 2 mg/mL] false] Water] Insoluble] false Purity: 99.84%
99.84

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Biological Activity

Description DM1 (Mertansine), an antibody-conjugatable maytansinoid, is a selective microtubule inhibitor that is developed to overcome systemic toxicity associated with maytansine and to enhance tumor-specific delivery. Mertansine can be attached to a monoclonal antibody with a linker to create an antibody-drug conjugate (ADC).Solutions are unstable and should be fresh-prepared.
Targets
Microtubule [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06138743 Not yet recruiting Myotonic Dystrophy 1 Arrowhead Pharmaceuticals January 2024 Phase 1
NCT05532813 Not yet recruiting Steinert''s Disease|Myotonic Dystrophy 1|Metformin Assistance Publique - Hôpitaux de Paris October 2023 Phase 3
NCT05945927 Recruiting Breast Cancer Hoffmann-La Roche September 13 2023 --
NCT04700046 Withdrawn Myotonic Dystrophy Type 1 and Type 2 Lupin Ltd. August 6 2023 Phase 3
NCT05388149 Recruiting Breast Cancer|HER2-positive Breast Cancer University Health Network Toronto December 6 2022 Phase 2

Chemical lnformation & Solubility

Molecular Weight 738.29 Formula

C35H48ClN3O10S
CAS No. 139504-50-0 SDF --
Smiles COC1\C=C\C=C(C)\CC2=CC(=C(Cl)C(=C2)OC)N(C)C(=O)CC(OC(=O)C(C)N(C)C(=O)CCS)C3(C)OC3C(C)C4CC1(O)NC(=O)O4
Storage (From the date of receipt) 3 years-20°C powder Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

In vitro
Batch:

DMSO : 50 mg/mL ( (67.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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