Home Metabolism P450 (e.g. CYP17) inhibitor Metyrapone For research use only.

Metyrapone

Synonyms: NSC-25265, SU-4885

Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.

Metyrapone Chemical Structure

Metyrapone Chemical Structure

CAS: 54-36-4

Selleck's Metyrapone has been cited by 1 publication

Purity & Quality Control

Batch: S541601 DMSO] 46 mg/mL] false] ] ] false] ] ] false Purity: 99.97%
99.97

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Biological Activity

Description Metyrapone (NSC-25265, SU-4885) is an inhibitor of the enzyme steroid 11-beta-monooxygenase (CYP11B1) that inhibits adrenal steroid synthesis.
Targets
11β-HSD1 [1]
30 μM(Ki)
In vitro
In vitro Metyrapone is a well known inhibitor of 11β-hydroxylase, a key enzyme involved in the final step of cortisol biosynthesis. At higher concentrations, it also inhibits other steroidogenic enzymes such as cholesterol side chain cleavage enzyme. It is specific for 11β-HSD1 while it has little effect on 11β-HSD2 activity[1].
In Vivo
In vivo The administration of metyrapone to man, and animals such as the dog and sheep thus leads to a decrease in circulating levels of cortisol[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03491696 Unknown status Depressive Disorder|Hormone Disturbance Centre Hospitalier Rouffach|University Hospital Strasbourg France December 22 2018 Phase 4
NCT02406066 Completed Cocaine Use Disorder|Tobacco Use Disorder Embera NeuroTherapeutics Inc.|National Institute on Drug Abuse (NIDA) March 2015 Phase 1

Chemical lnformation & Solubility

Molecular Weight 226.27 Formula

C14H14N2O
CAS No. 54-36-4 SDF --
Smiles CC(C)(C1=CN=CC=C1)C(=O)C2=CN=CC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 46 mg/mL ( (203.29 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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