Home Transmembrane Transporters Calcium Channel inhibitor Nicardipine For research use only.

Nicardipine

Nicardipine is a potent calcium channel blockader with marked vasodilator action.

Nicardipine Chemical Structure

Nicardipine Chemical Structure

CAS: 55985-32-5

Selleck's Nicardipine has been cited by 1 publication

Purity & Quality Control

Batch: S525501 DMSO] 95 mg/mL] false] Ethanol] 95 mg/mL] false] Water] 30 mg/mL] false Purity: 99%
99

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Biological Activity

Description Nicardipine is a potent calcium channel blockader with marked vasodilator action.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05164159 Completed Acute Cholecystitis Yonsei University February 20 2022 Not Applicable
NCT04137991 Completed Nociceptive Pain|Goal-directed Therapy|Hemodynamic Instability|Nol-Index|Remifentanil|Cardiac Surgery|Vascular Surgery|General Anesthesia Erasme University Hospital October 10 2019 Not Applicable
NCT01460563 Unknown status Cerebral Aneurysm Seoul National University Bundang Hospital October 2011 Not Applicable
NCT00325793 Unknown status Hypertension OSF Healthcare System|PDL BioPharma Inc. January 2004 Phase 4

Chemical lnformation & Solubility

Molecular Weight 479.52 Formula

C26H29N3O6
CAS No. 55985-32-5 SDF --
Smiles CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)CC2=CC=CC=C2)C3=CC(=CC=C3)[N+](=O)[O-])C(=O)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 95 mg/mL ( (198.11 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 95 mg/mL

Water : 30 mg/mL


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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