Home Transmembrane Transporters Proton Pump inhibitor - ATPase inhibitor Pantoprazole For research use only.

Pantoprazole

Synonyms: SKFSKF96022, BY-1023

Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.

Pantoprazole Chemical Structure

Pantoprazole Chemical Structure

CAS: 102625-70-7

Selleck's Pantoprazole has been cited by 4 publications

Purity & Quality Control

Batch: S210501 DMSO] 76 mg/mL] false] Ethanol] 76 mg/mL] false] Water] Insoluble] false Purity: 99.94%
99.94

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Biological Activity

Description Pantoprazole (SKF96022, BY-1023) is a proton pump inhibitor drug that inhibits gastric acid secretion. It works on gastric parietal cells to irreversibly inhibit (H+/K+)-ATPase function and suppress the production of gastric acid.
Targets
(H+/K+)-ATPase [1] Proton pump [1]
In vitro
In vitro PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]. Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole[3].
Cell Research Cell lines SGC-7901 cells
Concentrations 5 mg/ml
Incubation Time 24 h
Method

The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1x104/well, in 96-well plates and treated with 5 mg/ml PPZ for 24 h. The cytotoxicity of PPZ is assessed by a cell counting kit-8 assay. The cytotoxicity is expressed as the relative cell viability, using the following formula: Cell viability (%) = (OD of drug-treated sample/OD of untreated sample) x 100. The experiment is repeated 3 times.
In Vivo
In vivo i.p. injection of pantoprazole in HCT 116 colon tumor-bearing mice effectively suppresses cancer growth. The TOPK downstream signaling molecule phospho-histone H3 in tumor tissues is also decreased after pantoprazole treatment[3]. At higher infusion rates, pantoprazole is able to induce negative hemodynamic responses, in particular, in the setting of heart failure. These effects can lead to significant impairment of cardiac function[4]. Also, pantoprazole delays fracture healing by affecting both bone formation and bone remodeling[5].
Animal Research Animal Models Non-obese Diabetic/Severe Combined Immunodeficiency (NOD-SCID) mice
Dosages 100 mg/kg
Administration i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04248335 Recruiting Pediatric Obesity|NAFLD|GERD Children''s Mercy Hospital Kansas City July 3 2018 Phase 4
NCT02401035 Terminated Gastroesophageal Reflux Disease Pfizer May 9 2017 Phase 4
NCT02274961 Unknown status Non Erosive Reflux Disease Ahn-Gook Pharmaceuticals Co.Ltd October 2014 Phase 3
NCT02186652 Completed Gastroesophageal Reflux Disease Phillip Brian Smith|The Emmes Company LLC|Duke University June 4 2014 Phase 1
NCT01710462 Withdrawn Gastroesophageal Reflux Disease Eurofarma Laboratorios S.A. August 2013 Phase 3

Chemical lnformation & Solubility

Molecular Weight 383.37 Formula

C16H15F2N3O4S
CAS No. 102625-70-7 SDF Download Pantoprazole SDF
Smiles COC1=C(C(=NC=C1)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC(F)F)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 76 mg/mL ( (198.24 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 76 mg/mL

Water : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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