Home Metabolism PDE inhibitor Pentoxifylline For research use only.

Pentoxifylline

Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.

Pentoxifylline Chemical Structure

Pentoxifylline Chemical Structure

CAS: 6493-05-6

Selleck's Pentoxifylline has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.82%
99.82

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Biological Activity

Description Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity.
In vitro
In vitro Pentoxifylline exhibits synergism with CDDP in killing MCF-7/E6 cells but does not affect sensitivity of the control cells. Pentoxifylline inhibits G2 checkpoint function to a greater extent in MCF-7/E6 than in the parental cells. [1] Pentoxifylline acts primarily by increasing red blood cell deformability, by reducing blood viscosity and by decreasing the potential for platelet aggregation and thrombus formation. [2] Pentoxifylline is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity. Pentoxifylline (10 μM) suppresses the production of both biologically active TNF and TNF mRNA expression by more than 50% in LM cells. [3] Pentoxifylline blocks cachectin/TNF mRNA accumulation but has no effect upon the efficiency of reporter mRNA translation in RAW 264.7 macrophages. Pentoxifylline combined with Dexamethasone causes a greater suppression of cachectin/TNF biosynthesis that can be achieved by either agent alone in RAW 264.7 macrophages. [4]
In Vivo
In vivo Pentoxifylline (500 mg) markedly inhibits increases in the serum levels of TNF and IL-6, as well as the effects on coagulation and fibrinolysis, in chimpanzees. Pentoxifylline (500 mg) along with Endotoxin (4 ng/kg) also has a significant effect on thrombin generation in chimpanzees. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06041932 Not yet recruiting Liver Cirrhosis Institute of Liver and Biliary Sciences India November 1 2023 Not Applicable
NCT05490953 Recruiting Hodgkin Lymphoma University of Guadalajara|Hospital Civil de Guadalajara July 11 2022 Phase 4
NCT05189535 Recruiting Breast Cancer Female|Peripheral Neuropathy Ain Shams University October 3 2021 Phase 2|Phase 3
NCT04152980 Recruiting Neonatal Late Onset Sepsis Erasmus Medical Center January 12 2020 Phase 3
NCT05660694 Completed Triamcinolone|Pentoxifylline|Vitamin E|Oral Submucosa Fibrosis|Tumor Altamash Institute of Dental Medicine January 1 2020 Phase 4

Chemical lnformation & Solubility

Molecular Weight 278.31 Formula

C13H18N4O3
CAS No. 6493-05-6 SDF Download Pentoxifylline SDF
Smiles CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 55 mg/mL ( (197.62 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 55 mg/mL

Ethanol : 55 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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