Home Endocrinology & Hormones Sodium Channel inhibitor - Adrenergic Receptor antagonist Propafenone For research use only.

Propafenone

Synonyms: SA-79

Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.

Propafenone Chemical Structure

Propafenone Chemical Structure

CAS: 54063-53-5

Purity & Quality Control

Batch: S578901 DMSO] 68 mg/mL] false] Ethanol] 41 mg/mL] false] Water] Insoluble] false Purity: 99.90%
99.90

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Biological Activity

Description Propafenone (SA-79) is an orally active sodium channel blocking agent and a beta-adrenoceptor (β-adrenergic receptor) antagonist. Propafenone offers a broad spectrum of activity in the treatment of cardiac arrhythmias.
Targets
sodium channel [1] β-adrenergic receptor [1]
In vitro
In vitro

Application of 10 µM propafenone decreases the Kv currents by 51%, as measured at +60 mV.[2]
Cell Research Cell lines coronary arterial smooth muscle cells
Concentrations 10 µM
Incubation Time 2 min
Method

Tail currents, which were induced by a returning potential of −40 mV after short (20–50 ms ms) depolarizing steps from −80 to +60 mV in 10 mV increments, were used to obtain the steady-state activation curves. The recorded tail currents for each potential were normalized to the maximal tail current. Currents were recorded with a 600-ms test potential of +40 mV after 7-s pre-conditioning steps from −80 mV to +30 mV (10 mV increments) in the absence and presence of propafenone.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03915340 Completed Bioequivalence Pharmtechnology LLC|Altasciences Company Inc. March 23 2019 Phase 1
NCT03029169 Completed Supraventricular Arrhythmia|Septic Shock Charles University Czech Republic October 23 2017 Phase 4

Chemical lnformation & Solubility

Molecular Weight 341.44 Formula

C21H27NO3
CAS No. 54063-53-5 SDF --
Smiles CCCNCC(O)COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (199.15 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 41 mg/mL

Water : Insoluble


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In vivo
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