Home Transmembrane Transporters Sodium Channel inhibitor Ropivacaine HCl For research use only.

Ropivacaine HCl

Synonyms: LEA-103 HCl

Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.

Ropivacaine HCl Chemical Structure

Ropivacaine HCl Chemical Structure

CAS: 98717-15-8

Selleck's Ropivacaine HCl has been cited by 3 publications

Purity & Quality Control

Batch: S405801 DMSO] 62 mg/mL] false] Ethanol] 62 mg/mL] false] Water] 46 mg/mL] false Purity: 99.97%
99.97

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Biological Activity

Description Ropivacaine HCl (LEA-103) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly.
In vitro
In vitro Ropivacaine HCl is a local anaesthetic agent. Ropivacaine HCl elicits nerve block via reversible inhibition of sodium ion influx in nerve fibres. The pKa of ropivacaine HCl is ~8.2. Ropivacaine HCl has the potential to induce cardiovascular toxicity and CNS toxicity at high plasma concentrations. [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04003506 Not yet recruiting Pain Postoperative The University of Hong Kong March 1 2024 Phase 4
NCT06006026 Completed Colorectal Cancer West China Hospital August 28 2023 Not Applicable
NCT05773846 Recruiting Bunion PainReform LTD|Lotus Clinical Research LLC March 13 2023 Phase 3
NCT05594771 Not yet recruiting Labor Pain Women''s Hospital School Of Medicine Zhejiang University November 15 2022 Not Applicable

Chemical lnformation & Solubility

Molecular Weight 310.86 Formula

C17H26N2O.HCl
CAS No. 98717-15-8 SDF --
Smiles CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 62 mg/mL ( (199.44 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 62 mg/mL

Water : 46 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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