Home Immunology & Inflammation COX inhibitor S-(+)-Ketoprofen For research use only.

S-(+)-Ketoprofen

Synonyms: Actron, (S)-Ketoprofen, Dexketoprofen

S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.

S-(+)-Ketoprofen Chemical Structure

S-(+)-Ketoprofen Chemical Structure

CAS: 22161-81-5

Purity & Quality Control

Batch: S519201 DMSO] 51 mg/mL] false] Ethanol] 51 mg/mL] false] Water] Insoluble] false Purity: 99.93%
99.93

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Biological Activity

Description S-(+)-Ketoprofen (Compound 1, Actron, (S)-Ketoprofen, Dexketoprofen) is a potent inhibitor of cyclooxygenase (COX) with IC50 of 1.9 nM and 27 nM for COX-1 and COX-2, respectively.
Targets
COX-1 [1]
(Cell-free assay)		 COX-2 [1]
(Cell-free assay)
1.9 nM 27 nM
In vitro
In vitro

Ketoprofen combined with UVB irradiation induces the cytotoxicity and suppresses DNA synthesis in HaCaT cells in a concentration-dependent manner. Ketoprofen combined with UVB irradiation inhibits the cell growth and induces G2/M cell cycle arrest by modulating the levels of cdc2, cyclin B1, Chk1, Tyr15-phosphorylated cdc2 and p21. Ketoprofen combined with UVB irradiation also provokes a striking accumulation of cyclin B1-cdc2-p21 complexes, concomitantly with an increase in the levels of Tyr15-phosphorylated cdc2 and p21 protein. Ketoprofen combined with UVB irradiation accentuates the apoptotic response to UVB radiation in HaCaT cells as evidenced by DAPI staining. [1]
In Vivo
In vivo

Ketoprofen at 1% level in suitable topical vehicles can effectively inhibit GCF-LTB4 and GCF-PGE2 and positively alter alveolar bone activity in the ligature-induced model of periodontitis in the monkey. [2] Ketoprofen (3.63 mg/kg bwt) reduces hoof pain andlameness to a greater extent than the 2.2 mg/kg dose and phenylbutazone. [3] Ketoprofen is more effective than local anesthesia (LA), or caudal epidural anesthesia (EPI) in decreasing cortisol and partially reverses the reduction in average daily gain (ADG) following castration. [4] Ketoprofen (40 and 80 mg/kg diet) reduces the incidence of transitional cell carcinoma of the urinary bladder by >70% from that seen in dietary mice. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04657549 Completed Tonsillitis Recurrent|Tonsillitis Chronic Oulu University Hospital December 8 2020 Not Applicable
NCT02086097 Completed Irreversible Pulpitis Daniel Chavarría Bolaños|Universidad Autonoma de San Luis Potosí August 2013 Phase 4
NCT02568735 Completed Pain Postoperative Kuopio University Hospital January 2013 Phase 4

Chemical lnformation & Solubility

Molecular Weight 254.28 Formula
C16H14O3
CAS No. 22161-81-5 SDF --
Smiles CC(C(O)=O)C1=CC(=CC=C1)C(=O)C2=CC=CC=C2
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 51 mg/mL ( (200.56 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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