Home Metabolism PDE inhibitor Sildenafil Mesylate For research use only.

Sildenafil Mesylate

Synonyms: UK-92480 Mesylate

Sildenafil Mesylate(UK-92480 Mesylate) is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.

Sildenafil Mesylate Chemical Structure

Sildenafil Mesylate Chemical Structure

CAS: 1308285-21-3

Selleck's Sildenafil Mesylate has been cited by 4 publications

Purity & Quality Control

Batch: S468301 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 4 mg/mL] false Purity: 99.45%
99.45

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Biological Activity

Description Sildenafil Mesylate(UK-92480 Mesylate) is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
Targets
PDE5 [1]
In Vivo
In vivo

Chronic sildenafil treatment increases the detumescence phase in young and aged rats (p<0.05), although aged rats show a greater increase than young rats. Baseline cavernous PDE5 expression and activity are greater in aged vs young rats (p<0.05). After chronic sildenafil treatment cavernous PDE5 expression is increased in young (p<0.05) but not in aged rats. Chronic and acute sildenafil treatment similarly inhibits PDE5 activity in the penis of young and aged rats (p<0.05), coincident with its free plasma concentrations equivalent to clinically therapeutic ranges[2].
Animal Research Animal Models Male Fisher rats
Dosages 20 mg/kg
Administration s.c.

Chemical lnformation & Solubility

Molecular Weight 474.58(free base) Formula

C22H30N6O4S.xCH4O3S
CAS No. 1308285-21-3 SDF Download Sildenafil Mesylate SDF
Smiles CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C.CS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( ； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 4 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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