Home Microbiology Antibiotics chemical Tedizolid Phosphate For research use only.

Tedizolid Phosphate

Synonyms: TR-701FA

Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.

Tedizolid Phosphate Chemical Structure

Tedizolid Phosphate Chemical Structure

CAS: 856867-55-5

Selleck's Tedizolid Phosphate has been cited by 1 publication

Purity & Quality Control

Batch: S464101 DMSO] 22 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.86%
99.86

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Biological Activity

Description Tedizolid (TR-701FA) is an oxazolidinone-class antibiotic. Tedizolid phosphate is a phosphate ester prodrug of the active compound tedizolid.
In vitro
In vitro Tedizolid (TR-700, formerly torezolid) is the active moiety of the prodrug tedizolid phosphate (TR-701), a next-generation oxazolidinone, with high potency against Gram-positive species, including methicillin-resistant Staphylococcus aureus (MRSA)[2]. Tedizolid is 4-fold more potent than linezolid against PRSP isolates in vitro[1].
In Vivo
In vivo Tedizolid has excellent penetration into pulmonary epithelial lining fluid (ELF). Tedizolid phosphate administered to mice orally or intravenously is effective in vivo against systemic infection with PRSP isolates. Oral tedizolid phosphate is also effective in vivo against pneumonia induced with a PSSP strain[1].
Animal Research Animal Models Male ICR mice
Dosages 40 mg/kg of body weight, 13.33 mg/kg, 4.44 mg/kg, and 1.48 mg/kg
Administration oral administration; i.v.

Chemical lnformation & Solubility

Molecular Weight 450.32 Formula

C17H16FN6O6P
CAS No. 856867-55-5 SDF Download Tedizolid Phosphate SDF
Smiles CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4CC(OC4=O)COP(=O)(O)O)F
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 22 mg/mL ( (48.85 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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