Home Microbiology Reverse Transcriptase inhibitor Tenofovir alafenamide fumarate For research use only.

Tenofovir alafenamide fumarate

Synonyms: TAF fumarate, GS-7340 fumarate

Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.

Tenofovir alafenamide fumarate Chemical Structure

Tenofovir alafenamide fumarate Chemical Structure

CAS: 379270-38-9

Selleck's Tenofovir alafenamide fumarate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.92%
99.92

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Biological Activity

Description Tenofovir alafenamide (TAF, GS-7340) fumarate is a prodrug of tenofovir but results in significantly higher intracellular tenofovir concentrations and lower serum levels. Tenofovir alafenamide is a novel nucleotide reverse transcriptase inhibitor for the treatment of HIV-1 infection.
Targets
reverse transcriptase [1]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05652478 Recruiting Metabolic Effects|Weight Gain|HIV|Integrase Strand Transfer Inhibitors National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) January 12 2024 Phase 2
NCT06104306 Recruiting HIV-1-infection Gilead Sciences December 13 2023 Phase 4
NCT05583006 Recruiting Patient Satisfaction|Drug Adherence|Efficacy Self|Safety Issues Taichung Veterans General Hospital|Institute of Adherence to Medication November 6 2023 --
NCT05924438 Recruiting HIV-1-infection Professor Francois Venter|Africa Health Research Institute|Merck Sharp & Dohme LLC|University of Witwatersrand South Africa November 8 2023 Phase 3

Chemical lnformation & Solubility

Molecular Weight 592.54 Formula

C25H33N6O9P
CAS No. 379270-38-9 SDF --
Smiles CC(C)OC(=O)C(C)N[P](=O)(COC(C)C[N]1C=NC2=C(N)N=CN=C12)OC3=CC=CC=C3.OC(=O)\C=C\C(O)=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (168.76 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 100 mg/mL

Water : 10 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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