Home Microbiology Parasite inhibitor Tetramisole HCl For research use only.

Tetramisole HCl

Synonyms: R-829,(±)-Tetramisole hydrochloride

Tetramisole(R-829,(±)-Tetramisole hydrochloride) is a mixture of dextro- and levo isomers used as an anthelmintic.

Tetramisole HCl Chemical Structure

Tetramisole HCl Chemical Structure

CAS: 5086-74-8

Purity & Quality Control

Batch: S409401 Water] 41 mg/mL] false] DMSO] Insoluble] false] Ethanol] Insoluble] false Purity: 99.81%
99.81

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Biological Activity

Description Tetramisole(R-829,(±)-Tetramisole hydrochloride) is a mixture of dextro- and levo isomers used as an anthelmintic.
In vitro
In vitro

Tetramisole is active at low, atoxic oral and parenteral dose levels against all adult and immature gastrointestinal and pulmonary nematodes tested in 14 different hosts. [1] Tetramisole (10 μg/mL) causes a sustained contraction of the isolated somatic muscles of the worm. Tetramisole reduces the resting potential of Ascaris muscle from 34 mV to 10 mV. Tetramisole causes contraction of Ascaris muscle previously depolarized with high K+ solutions. [2] Tetramisole (0.1 mM) augmentes the twitch responses of both the directly and indirectly stimulated muscle in cats. Tetramisole (0.1 mM) increases the twitch response of the preparation and reverses the blocking action of tubocurarine in chickens. Tetramisole (0.1 mM) produces reversible neuromuscular block and contracture of the muscle in chickens. [3]
In Vivo
In vivo

Tetramisole (2 mg/kg, i.v.) after a delay of 20 s, produces a strong contraction of the nictitating membrane in the cat which is accompanied by a small brief fall in blood pressure followed by a sustained rise that persisted for up to 20 min. Tetramisole (2 mg/kg) elicites a greater contractile response in the membrane than in non-reserpinized cats. Tetramisole (5-10 mg/kg, i.v.) causes a sharp transient fall in blood pressure in rabbits which is partially antagonized by atropine. [3] Tetramisole (15 mg/kg) rises the mean faecal egg count from 3 weeks after treatment and remaines continuously higher up to 12 weeks in sheeps. [4]

Chemical lnformation & Solubility

Molecular Weight 240.75 Formula

C11H12N2S.HCl
CAS No. 5086-74-8 SDF Download Tetramisole HCl SDF
Smiles C1CSC2=NC(CN21)C3=CC=CC=C3.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 41 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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