Home Microbiology Antibiotics chemical Tilmicosin For research use only.

Tilmicosin

Synonyms: EL 870,LY-177370

Tilmicosin (EL 870,LY-177370) is a macrolide antibiotic.

Tilmicosin Chemical Structure

Tilmicosin Chemical Structure

CAS: 108050-54-0

Purity & Quality Control

Batch: Purity: 99.02%
99.02

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Biological Activity

Description Tilmicosin (EL 870,LY-177370) is a macrolide antibiotic.
In vitro
In vitro

Tilmicosin inhibits growth of Pasteurella multocida, Pasteurella haemolytica, Mycoplasma hyopneumoniae, Actinobacillus pleuropneumoniae, Streptococcus suis, Actinomyces pyogenes and certain other bacteria at levels of 6.25 μg/mL or less. In general, the MICs for Gram-negative enteric bacteria have been greater than 50 μg/mL. [1] Tilmicosin causes decreases in cardiac SOD and GPX activities. [3]
In Vivo
In vivo

After a subcutaneous injection, tilmicosin is eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin is more than 1 L/kg. The peak serum tilmicosin concentration is 1.56 μg/mL. 6.39 hours after a subcutaneous injection of 10 mg/kg. Tilmicosin is extensively secreted into milk, reaching a maximum concentration of 11.6 μg/mL and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin is detectable in milk for 11 days after a single subcutaneous dose.[2]

Chemical lnformation & Solubility

Molecular Weight 869.13 Formula

C46H80N2O13
CAS No. 108050-54-0 SDF Download Tilmicosin SDF
Smiles CCC1C(C=C(C=CC(=O)C(CC(C(C(C(CC(=O)O1)O)C)OC2C(C(C(C(O2)C)O)N(C)C)O)CCN3CC(CC(C3)C)C)C)C)COC4C(C(C(C(O4)C)O)OC)OC
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 100 mg/mL ( (115.05 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 8 mg/mL

Ethanol : Insoluble


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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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