Home Microbiology Parasite inhibitor Tinidazole For research use only.

Tinidazole

Synonyms: CP12574

Tinidazole (CP12574) is an anti-parasitic drug.

Tinidazole Chemical Structure

Tinidazole Chemical Structure

CAS: 19387-91-8

Selleck's Tinidazole has been cited by 1 publication

Purity & Quality Control

Batch: S406801 DMSO] 49 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.94%
99.94

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Biological Activity

Description Tinidazole (CP12574) is an anti-parasitic drug.
In vitro
In vitro Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. [1] Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. [2] Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. [3] Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. [4] Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05383521 Not yet recruiting Trichomonas Vaginitis Shangrong Fan|Peking University Shenzhen Hospital December 1 2023 Not Applicable
NCT00324142 Withdrawn Recurrent Bacterial Vaginosis Kaiser Permanente Phase 2

Chemical lnformation & Solubility

Molecular Weight 247.27 Formula

C8H13N3O4S
CAS No. 19387-91-8 SDF Download Tinidazole SDF
Smiles CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 49 mg/mL ( (198.16 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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