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Trihexyphenidyl hydrochloride

Name: Trihexyphenidyl hydrochloride
Brand: Selleck Chemicals
SKU: S4542

Synonyms: Benzhexol hydrochloride, Artane hydrochloride

Catalog No.S4542 Purity: 99.96%

Trihexyphenidyl hydrochloride (Benzhexol, Artane) is an antiparkinsonian agent of the antimuscarinic class.

Trihexyphenidyl hydrochloride Chemical Structure

CAS: 52-49-3

Purity & Quality Control

Batch: Purity: 99.96%

99.96

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Biological Activity

Description	Trihexyphenidyl hydrochloride (Benzhexol, Artane) is an antiparkinsonian agent of the antimuscarinic class.

In Vivo
In vivo	Trihexyphenidyl-treated rats exhibits significantly extended mean latencies during the initial 3 months of testing; however, this behavioral deficit is restored between the fourth and sixth month of MWM testing. The most significant populations of genes downregulated by THP are the immune response-, antigen processing and presentation-, and major histocompatibility complex (MHC)-related genes, as validated by qRT-PCR. In aging brains, THP treatment decreases expression of MHC class I. Its long-term treatment primes hippocampal and cortical microglia to undergo an inflammatory phenotypic switch, causing microgliosis and microglia activation, which are positively accompanied by pathological misfolded tau lesions^[1].TPH induces dose-dependent structural changes in rat frontal cortex motor area^[2].
Animal Research	Animal Models	Male Sprague-Dawley rats (SD)
	Dosages	0.3 and 1.0 mg/kg
	Administration	i.p.

References

Chemical lnformation & Solubility

Molecular Weight	337.93	Formula	C₂₀H₃₁NO.HCl
CAS No.	52-49-3	SDF	Download Trihexyphenidyl hydrochloride SDF
Smiles	C1CCC(CC1)C(CCN2CCCCC2)(C3=CC=CC=C3)O.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 20 mg/mL ( (59.18 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 20 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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