Home Angiogenesis HIF modulator Vadadustat For research use only.

Vadadustat

Synonyms: AKB-6548, B-506, PG-1016548

Vadadustat (AKB-6548, B-506, PG-1016548) is a novel, titratable, oral HIF-PH inhibitor.

Vadadustat Chemical Structure

Vadadustat Chemical Structure

CAS: 1000025-07-9

Selleck's Vadadustat has been cited by 1 publication

Purity & Quality Control

Batch: S649001 DMSO] 61 mg/mL] false] Ethanol] 9 mg/mL] false] Water] Insoluble] false Purity: 99.56%
99.56

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Biological Activity

Description Vadadustat (AKB-6548, B-506, PG-1016548) is a novel, titratable, oral HIF-PH inhibitor.
Targets
PH2 [1] FIH(factor inhibiting HIF) [1]
0.029 μM 29 μM
In vitro
In vitro

Vadadustat works by active site iron chelating mechanisms in terms of inhibiting isolated PHD2[1].
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05082584 Suspended Anemia of Chronic Kidney Disease Akebia Therapeutics January 2025 Phase 3
NCT05082571 Suspended Anemia of Chronic Kidney Disease Akebia Therapeutics January 2025 Phase 3
NCT03992066 Completed Anemia Associated With Chronic Kidney Disease Akebia Therapeutics May 28 2019 Phase 1
NCT03799627 Completed Anemia|Dialysis-dependent Chronic Kidney Disease Akebia Therapeutics January 31 2019 Phase 2
NCT03789032 Completed Drug Interaction Potentiation|Pharmacokinetics Akebia Therapeutics October 3 2018 Phase 1

Chemical lnformation & Solubility

Molecular Weight 306.70 Formula

C14H11ClN2O4
CAS No. 1000025-07-9 SDF --
Smiles C1=CC(=CC(=C1)Cl)C2=CC(=C(N=C2)C(=O)NCC(=O)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 61 mg/mL ( (198.89 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 9 mg/mL

Water : Insoluble


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In vivo
Batch:

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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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