Home Metabolism PDE inhibitor Vardenafil hydrochloride For research use only.

Vardenafil hydrochloride

Synonyms: BAY38-9456, Levitra, Staxyn

Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.

Vardenafil hydrochloride Chemical Structure

Vardenafil hydrochloride Chemical Structure

CAS: 224785-91-5

Selleck's Vardenafil hydrochloride has been cited by 1 publication

Purity & Quality Control

Batch: S595701 DMSO] 100 mg/mL] false] Water] 100 mg/mL] false] Ethanol] 20 mg/mL] false Purity: 99.53%
99.53

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Biological Activity

Description Vardenafil (BAY38-9456, Levitra, Staxyn) hydrochloride is a selective, orally active, potent inhibitor of phosphodiesterase (PDE) with IC50 of 0.7 nM, 11 nM and 180 nM for PDE5, PDE6 and PDE1, respectively.
Targets
PDE5 [1]
(Cell-free assay)		 PDE6 [1]
(Cell-free assay)		 PDE1 [1]
(Cell-free assay)
0.7 nM 11 nM 180 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01207947 Completed Erectile Dysfunction Bayer October 2007 --
NCT00909233 Completed Erectile Dysfunction Bayer August 2007 --

Chemical lnformation & Solubility

Molecular Weight 525.06 Formula

C23H33ClN6O4S
CAS No. 224785-91-5 SDF --
Smiles Cl.CCCC1=NC(=C2[N]1NC(=NC2=O)C3=C(OCC)C=CC(=C3)[S](=O)(=O)N4CCN(CC)CC4)C
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (190.45 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 100 mg/mL

Ethanol : 20 mg/mL


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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