Home DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor - Autophagy activator - Nucleoside Analog/Antimetabolite inhibitor Gemcitabine HCl For research use only.

Gemcitabine HCl

Synonyms: NSC 613327 HCl,LY-188011 HCl

Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.

Gemcitabine HCl Chemical Structure

Gemcitabine HCl Chemical Structure

CAS: 122111-03-9

Selleck's Gemcitabine HCl has been cited by 178 publications

Purity & Quality Control

Batch: Purity: 99.96%
99.96

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Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CCRF-CEM Growth Inhibition Assay IC50=2.9 ± 1.8 nM 22425885
CCRF-CEM/dCK−/− Growth Inhibition Assay IC50=240.4 ± 29.0 μM 22425885
L1210 wt Growth Inhibition Assay IC50=1.3 ± 0.3 nM 22425885
L1210 10K Growth Inhibition Assay IC50=22.2 ± 3.7 μM 22425885
TC-1  Growth Inhibition Assay IC50=14.7 ± 2.8 nM 22425885
TC-1-GR Growth Inhibition Assay IC50=36.7 ± 5.1 μM 22425885
MIA PaCa-2 Growth Inhibition Assay IC50=49.7 ± 17.7 nM 22425885
PANC-1 Growth Inhibition Assay IC50=> 400 μM 22425885
CCRF-CEM Growth Inhibition Assay IC50=2.9 ± 1.8 nM 22425885
CCRF-CEM-AraC-8C Growth Inhibition Assay IC50=998.8 ± 9.4 nM 22425885
CCRF-CEM  Growth Inhibition Assay 72 h IC50=2.0 ± 0.6 nM 21851843
MV-4-11 Growth inhibition assay IC50 = 0.0005 nM SANGER
ES4 Growth inhibition assay IC50 = 0.0007 nM SANGER
ACHN Growth inhibition assay IC50 = 0.0009 nM SANGER
KYSE-510 Growth inhibition assay IC50 = 0.001 nM SANGER
EW-7 Growth inhibition assay IC50 = 0.0026 nM SANGER
BFTC-905 Growth inhibition assay IC50 = 0.0051 nM SANGER
KE-37 Growth inhibition assay IC50 = 0.0056 nM SANGER
SBC-5 Growth inhibition assay IC50 = 0.0057 nM SANGER
NKM-1 Growth inhibition assay IC50 = 0.0071 nM SANGER
RH-1 Growth inhibition assay IC50 = 0.0072 nM SANGER
ALL-PO Growth inhibition assay IC50 = 0.0083 nM SANGER
QIMR-WIL Growth inhibition assay IC50 = 0.0089 nM SANGER
A375 Growth inhibition assay IC50 = 0.0099 nM SANGER
SIG-M5 Growth inhibition assay IC50 = 0.0104 nM SANGER
KGN Growth inhibition assay IC50 = 0.0108 nM SANGER
EW-13 Growth inhibition assay IC50 = 0.0112 nM SANGER
NCI-SNU-1 Growth inhibition assay IC50 = 0.016 nM SANGER
PSN1 Growth inhibition assay IC50 = 0.0165 nM SANGER
HUTU-80 Growth inhibition assay IC50 = 0.0166 nM SANGER
786-0 Growth inhibition assay IC50 = 0.023 nM SANGER
EW-16 Growth inhibition assay IC50 = 0.023 nM SANGER
ES1 Growth inhibition assay IC50 = 0.0268 nM SANGER
RKO Growth inhibition assay IC50 = 0.0278 nM SANGER
ESS-1 Growth inhibition assay IC50 = 0.0286 nM SANGER
SK-UT-1 Growth inhibition assay IC50 = 0.0297 nM SANGER
LB2241-RCC Growth inhibition assay IC50 = 0.0318 nM SANGER
CHL-1 Growth inhibition assay IC50 = 0.0324 nM SANGER
SW1783 Growth inhibition assay IC50 = 0.0336 nM SANGER
MEL-JUSO Growth inhibition assay IC50 = 0.0391 nM SANGER
HT-29 Growth inhibition assay IC50 = 0.0413 nM SANGER
SNG-M Growth inhibition assay IC50 = 0.0425 nM SANGER
TE-15 Growth inhibition assay IC50 = 0.0464 nM SANGER
HOS Growth inhibition assay IC50 = 0.048 nM SANGER
BB65-RCC Growth inhibition assay IC50 = 0.0512 nM SANGER
HCE-4 Growth inhibition assay IC50 = 0.0528 nM SANGER
MHH-ES-1 Growth inhibition assay IC50 = 0.0531 nM SANGER
RPMI-7951 Growth inhibition assay IC50 = 0.0541 nM SANGER
IST-SL2 Growth inhibition assay IC50 = 0.0584 nM SANGER
CMK Growth inhibition assay IC50 = 0.0586 nM SANGER
GR-ST Growth inhibition assay IC50 = 0.0595 nM SANGER
NALM-6 Growth inhibition assay IC50 = 0.0622 nM SANGER
RPMI-6666 Growth inhibition assay IC50 = 0.0652 nM SANGER
LC-2-ad Growth inhibition assay IC50 = 0.0653 nM SANGER
ARH-77 Growth inhibition assay IC50 = 0.0711 nM SANGER
IST-MEL1 Growth inhibition assay IC50 = 0.0726 nM SANGER
SW1710 Growth inhibition assay IC50 = 0.0751 nM SANGER
DEL Growth inhibition assay IC50 = 0.0887 nM SANGER
AGS Growth inhibition assay IC50 = 0.0902 nM SANGER
NCI-H2122 Growth inhibition assay IC50 = 0.0945 nM SANGER
HSC-4 Growth inhibition assay IC50 = 0.1022 nM SANGER
AM-38 Growth inhibition assay IC50 = 0.1215 nM SANGER
769-P Growth inhibition assay IC50 = 0.1231 nM SANGER
RT-112 Growth inhibition assay IC50 = 0.1273 nM SANGER
MCF7 Growth inhibition assay IC50 = 0.1359 nM SANGER
IGROV-1 Growth inhibition assay IC50 = 0.145 nM SANGER
OCI-AML2 Growth inhibition assay IC50 = 0.1466 nM SANGER
NCI-H1299 Growth inhibition assay IC50 = 0.1566 nM SANGER
A431 Growth inhibition assay IC50 = 0.1831 nM SANGER
SW982 Growth inhibition assay IC50 = 0.2133 nM SANGER
BB30-HNC Growth inhibition assay IC50 = 0.2312 nM SANGER
ACN Growth inhibition assay IC50 = 0.2436 nM SANGER
647-V Growth inhibition assay IC50 = 0.2481 nM SANGER
SK-PN-DW Growth inhibition assay IC50 = 0.2656 nM SANGER
LCLC-97TM1 Growth inhibition assay IC50 = 0.2673 nM SANGER
LB1047-RCC Growth inhibition assay IC50 = 0.2688 nM SANGER
A2780 Growth inhibition assay IC50 = 0.2702 nM SANGER
C-33-A Growth inhibition assay IC50 = 0.2733 nM SANGER
NCI-H2228 Growth inhibition assay IC50 = 0.314 nM SANGER
TE-5 Growth inhibition assay IC50 = 0.3157 nM SANGER
HC-1 Growth inhibition assay IC50 = 0.3273 nM SANGER
SK-MES-1 Growth inhibition assay IC50 = 0.3279 nM SANGER
NCI-H1355 Growth inhibition assay IC50 = 0.3806 nM SANGER
YKG-1 Growth inhibition assay IC50 = 0.4194 nM SANGER
RS4-11 Growth inhibition assay IC50 = 0.4326 nM SANGER
Daoy Growth inhibition assay IC50 = 0.4565 nM SANGER
A3-KAW Growth inhibition assay IC50 = 0.5512 nM SANGER
SK-MEL-30 Growth inhibition assay IC50 = 0.5545 nM SANGER
U031 Growth inhibition assay IC50 = 0.5647 nM SANGER
SK-LMS-1 Growth inhibition assay IC50 = 0.5776 nM SANGER
ES6 Growth inhibition assay IC50 = 0.5856 nM SANGER
EoL-1-cell Growth inhibition assay IC50 = 0.6162 nM SANGER
NCI-H2009 Growth inhibition assay IC50 = 0.6187 nM SANGER
A4-Fuk Growth inhibition assay IC50 = 0.6263 nM SANGER
KYSE-270 Growth inhibition assay IC50 = 0.6341 nM SANGER
SK-LU-1 Growth inhibition assay IC50 = 0.6552 nM SANGER
SW872 Growth inhibition assay IC50 = 0.7647 nM SANGER
ES8 Growth inhibition assay IC50 = 0.7802 nM SANGER
G-402 Growth inhibition assay IC50 = 0.7844 nM SANGER
ATN-1 Growth inhibition assay IC50 = 0.8069 nM SANGER
DoTc2-4510 Growth inhibition assay IC50 = 0.9012 nM SANGER
MES-SA Growth inhibition assay IC50 = 0.9049 nM SANGER
SF268 Growth inhibition assay IC50 = 0.9274 nM SANGER
SF539 Growth inhibition assay IC50 = 1.023 nM SANGER
NB69 Growth inhibition assay IC50 = 1.046 nM SANGER
8505C Growth inhibition assay IC50 = 1.063 nM SANGER
CAL-12T Growth inhibition assay IC50 = 1.084 nM SANGER
BHY Growth inhibition assay IC50 = 1.141 nM SANGER
LB647-SCLC Growth inhibition assay IC50 = 1.18 nM SANGER
CAL-62 Growth inhibition assay IC50 = 1.215 nM SANGER
MEG-01 Growth inhibition assay IC50 = 1.266 nM SANGER
MG-63 Growth inhibition assay IC50 = 1.335 nM SANGER
SW620 Growth inhibition assay IC50 = 1.346 nM SANGER
A388 Growth inhibition assay IC50 = 1.365 nM SANGER
BCPAP Growth inhibition assay IC50 = 1.452 nM SANGER
P30-OHK Growth inhibition assay IC50 = 1.459 nM SANGER
Ca9-22 Growth inhibition assay IC50 = 1.538 nM SANGER
VMRC-RCZ Growth inhibition assay IC50 = 1.542 nM SANGER
LOXIMVI Growth inhibition assay IC50 = 1.596 nM SANGER
L-540 Growth inhibition assay IC50 = 1.602 nM SANGER
NTERA-S-cl-D1 Growth inhibition assay IC50 = 1.641 nM SANGER
MFH-ino Growth inhibition assay IC50 = 1.656 nM SANGER
Calu-6 Growth inhibition assay IC50 = 1.735 nM SANGER
HEL Growth inhibition assay IC50 = 1.791 nM SANGER
CAL-33 Growth inhibition assay IC50 = 1.893 nM SANGER
HSC-3 Growth inhibition assay IC50 = 1.905 nM SANGER
KU812 Growth inhibition assay IC50 = 1.913 nM SANGER
EB2 Growth inhibition assay IC50 = 2.012 nM SANGER
SR Growth inhibition assay IC50 = 2.121 nM SANGER
NCI-H2087 Growth inhibition assay IC50 = 2.143 nM SANGER
H4 Growth inhibition assay IC50 = 2.175 nM SANGER
EW-1 Growth inhibition assay IC50 = 2.223 nM SANGER
MC-IXC Growth inhibition assay IC50 = 2.264 nM SANGER
NCI-H727 Growth inhibition assay IC50 = 2.506 nM SANGER
MRK-nu-1 Growth inhibition assay IC50 = 2.567 nM SANGER
COLO-668 Growth inhibition assay IC50 = 2.66 nM SANGER
CGTH-W-1 Growth inhibition assay IC50 = 2.723 nM SANGER
CHP-212 Growth inhibition assay IC50 = 2.752 nM SANGER
GI-1 Growth inhibition assay IC50 = 2.764 nM SANGER
HCC1806 Growth inhibition assay IC50 = 2.908 nM SANGER
HLE Growth inhibition assay IC50 = 3.004 nM SANGER
HSC-2 Growth inhibition assay IC50 = 3.03 nM SANGER
DMS-273 Growth inhibition assay IC50 = 3.07 nM SANGER
DU-4475 Growth inhibition assay IC50 = 3.143 nM SANGER
LXF-289 Growth inhibition assay IC50 = 3.314 nM SANGER
PANC-03-27 Growth inhibition assay IC50 = 3.513 nM SANGER
GAMG Growth inhibition assay IC50 = 3.739 nM SANGER
NCI-H522 Growth inhibition assay IC50 = 4.337 nM SANGER
SW626 Growth inhibition assay IC50 = 4.464 nM SANGER
HT-144 Growth inhibition assay IC50 = 4.92 nM SANGER
MEL-HO Growth inhibition assay IC50 = 5.162 nM SANGER
BE-13 Growth inhibition assay IC50 = 5.21 nM SANGER
VA-ES-BJ Growth inhibition assay IC50 = 5.256 nM SANGER
NCI-H441 Growth inhibition assay IC50 = 5.597 nM SANGER
KP-4 Growth inhibition assay IC50 = 5.611 nM SANGER
LoVo Growth inhibition assay IC50 = 5.714 nM SANGER
HT-1080 Growth inhibition assay IC50 = 5.834 nM SANGER
GB-1 Growth inhibition assay IC50 = 5.845 nM SANGER
IA-LM Growth inhibition assay IC50 = 5.906 nM SANGER
8-MG-BA Growth inhibition assay IC50 = 5.93 nM SANGER
SK-HEP-1 Growth inhibition assay IC50 = 6.136 nM SANGER
697 Growth inhibition assay IC50 = 6.247 nM SANGER
KYSE-450 Growth inhibition assay IC50 = 6.315 nM SANGER
HCC2998 Growth inhibition assay IC50 = 6.339 nM SANGER
HD-MY-Z Growth inhibition assay IC50 = 6.679 nM SANGER
OS-RC-2 Growth inhibition assay IC50 = 6.681 nM SANGER
SF126 Growth inhibition assay IC50 = 7.054 nM SANGER
Ca-Ski Growth inhibition assay IC50 = 7.093 nM SANGER
NCI-H358 Growth inhibition assay IC50 = 7.16 nM SANGER
J82 Growth inhibition assay IC50 = 7.41 nM SANGER
NCI-H2342 Growth inhibition assay IC50 = 7.634 nM SANGER
OVCAR-8 Growth inhibition assay IC50 = 7.904 nM SANGER
TE-8 Growth inhibition assay IC50 = 8.001 nM SANGER
ETK-1 Growth inhibition assay IC50 = 8.076 nM SANGER
HAL-01 Growth inhibition assay IC50 = 8.195 nM SANGER
KYSE-150 Growth inhibition assay IC50 = 8.469 nM SANGER
NCI-H810 Growth inhibition assay IC50 = 8.558 nM SANGER
ONS-76 Growth inhibition assay IC50 = 8.677 nM SANGER
NMC-G1 Growth inhibition assay IC50 = 8.762 nM SANGER
C3A Growth inhibition assay IC50 = 8.839 nM SANGER
PA-1 Growth inhibition assay IC50 = 8.993 nM SANGER
SH-4 Growth inhibition assay IC50 = 9.022 nM SANGER
EFO-27 Growth inhibition assay IC50 = 9.046 nM SANGER
CAPAN-1 Growth inhibition assay IC50 = 9.227 nM SANGER
DU-145 Growth inhibition assay IC50 = 9.29 nM SANGER
A101D Growth inhibition assay IC50 = 9.373 nM SANGER
ST486 Growth inhibition assay IC50 = 9.406 nM SANGER
NCI-H1437 Growth inhibition assay IC50 = 9.418 nM SANGER
HGC-27 Growth inhibition assay IC50 = 9.601 nM SANGER
8305C Growth inhibition assay IC50 = 9.64 nM SANGER
OCUB-M Growth inhibition assay IC50 = 10.03 nM SANGER
COLO-679 Growth inhibition assay IC50 = 10.07 nM SANGER
Detroit562 Growth inhibition assay IC50 = 10.42 nM SANGER
A204 Growth inhibition assay IC50 = 11.16 nM SANGER
NCI-H1734 Growth inhibition assay IC50 = 11.29 nM SANGER
MC-CAR Growth inhibition assay IC50 = 11.58 nM SANGER
NCI-H2170 Growth inhibition assay IC50 = 11.97 nM SANGER
NCI-SNU-5 Growth inhibition assay IC50 = 12.13 nM SANGER
HCE-T Growth inhibition assay IC50 = 12.42 nM SANGER
KYSE-180 Growth inhibition assay IC50 = 12.81 nM SANGER
C8166 Growth inhibition assay IC50 = 13.08 nM SANGER
NCI-H460 Growth inhibition assay IC50 = 13.54 nM SANGER
SNU-449 Growth inhibition assay IC50 = 13.77 nM SANGER
MDA-MB-468 Growth inhibition assay IC50 = 14.12 nM SANGER
COR-L23 Growth inhibition assay IC50 = 14.13 nM SANGER
CTV-1 Growth inhibition assay IC50 = 14.14 nM SANGER
BL-41 Growth inhibition assay IC50 = 14.37 nM SANGER
IGR-1 Growth inhibition assay IC50 = 14.42 nM SANGER
TK10 Growth inhibition assay IC50 = 14.49 nM SANGER
REH Growth inhibition assay IC50 = 14.51 nM SANGER
LU-139 Growth inhibition assay IC50 = 14.59 nM SANGER
KP-N-YS Growth inhibition assay IC50 = 14.97 nM SANGER
PANC-10-05 Growth inhibition assay IC50 = 15.38 nM SANGER
HL-60 Growth inhibition assay IC50 = 15.69 nM SANGER
T84 Growth inhibition assay IC50 = 15.96 nM SANGER
RPMI-8226 Growth inhibition assay IC50 = 16.02 nM SANGER
UM-UC-3 Growth inhibition assay IC50 = 16.16 nM SANGER
TE-10 Growth inhibition assay IC50 = 16.21 nM SANGER
CAL-148 Growth inhibition assay IC50 = 17.23 nM SANGER
BV-173 Growth inhibition assay IC50 = 17.27 nM SANGER
Calu-3 Growth inhibition assay IC50 = 17.29 nM SANGER
RPMI-2650 Growth inhibition assay IC50 = 17.59 nM SANGER
MKN45 Growth inhibition assay IC50 = 17.73 nM SANGER
NUGC-3 Growth inhibition assay IC50 = 18.34 nM SANGER
NCI-H520 Growth inhibition assay IC50 = 18.77 nM SANGER
CCRF-CEM Growth inhibition assay IC50 = 18.85 nM SANGER
NCI-H2405 Growth inhibition assay IC50 = 19.1 nM SANGER
ES7 Growth inhibition assay IC50 = 19.76 nM SANGER
BPH-1 Growth inhibition assay IC50 = 20.28 nM SANGER
SAS Growth inhibition assay IC50 = 20.5 nM SANGER
HuCCT1 Growth inhibition assay IC50 = 20.58 nM SANGER
LOUCY Growth inhibition assay IC50 = 20.66 nM SANGER
NCI-H292 Growth inhibition assay IC50 = 20.79 nM SANGER
G-361 Growth inhibition assay IC50 = 21.07 nM SANGER
M059J Growth inhibition assay IC50 = 21.08 nM SANGER
NCI-H1651 Growth inhibition assay IC50 = 21.11 nM SANGER
KALS-1 Growth inhibition assay IC50 = 21.39 nM SANGER
DJM-1 Growth inhibition assay IC50 = 21.59 nM SANGER
AU565 Growth inhibition assay IC50 = 21.83 nM SANGER
HCC38 Growth inhibition assay IC50 = 21.95 nM SANGER
U251 Growth inhibition assay IC50 = 22.27 nM SANGER
ABC-1 Growth inhibition assay IC50 = 22.65 nM SANGER
SK-NEP-1 Growth inhibition assay IC50 = 22.93 nM SANGER
CESS Growth inhibition assay IC50 = 23.19 nM SANGER
MIA-PaCa-2 Growth inhibition assay IC50 = 23.36 nM SANGER
SUP-T1 Growth inhibition assay IC50 = 23.47 nM SANGER
L-428 Growth inhibition assay IC50 = 23.62 nM SANGER
SW954 Growth inhibition assay IC50 = 23.68 nM SANGER
HO-1-N-1 Growth inhibition assay IC50 = 23.77 nM SANGER
CHP-126 Growth inhibition assay IC50 = 24.14 nM SANGER
HMV-II Growth inhibition assay IC50 = 24.34 nM SANGER
NB10 Growth inhibition assay IC50 = 24.37 nM SANGER
A172 Growth inhibition assay IC50 = 24.71 nM SANGER
MONO-MAC-6 Growth inhibition assay IC50 = 24.84 nM SANGER
NCI-H1650 Growth inhibition assay IC50 = 25.4 nM SANGER
NH-12 Growth inhibition assay IC50 = 25.5 nM SANGER
ML-2 Growth inhibition assay IC50 = 25.74 nM SANGER
MZ2-MEL Growth inhibition assay IC50 = 26.22 nM SANGER
COLO-684 Growth inhibition assay IC50 = 26.41 nM SANGER
HuP-T4 Growth inhibition assay IC50 = 27.3 nM SANGER
SW837 Growth inhibition assay IC50 = 27.62 nM SANGER
MDA-MB-231 Growth inhibition assay IC50 = 27.78 nM SANGER
KYSE-140 Growth inhibition assay IC50 = 27.91 nM SANGER
NOMO-1 Growth inhibition assay IC50 = 28.68 nM SANGER
GP5d Growth inhibition assay IC50 = 28.72 nM SANGER
COR-L105 Growth inhibition assay IC50 = 29.42 nM SANGER
LS-411N Growth inhibition assay IC50 = 29.88 nM SANGER
NY Growth inhibition assay IC50 = 30.18 nM SANGER
NCI-H2030 Growth inhibition assay IC50 = 30.45 nM SANGER
CCF-STTG1 Growth inhibition assay IC50 = 31.42 nM SANGER
NCI-H1703 Growth inhibition assay IC50 = 31.78 nM SANGER
TUR Growth inhibition assay IC50 = 32.03 nM SANGER
NOS-1 Growth inhibition assay IC50 = 32.44 nM SANGER
A2058 Growth inhibition assay IC50 = 32.83 nM SANGER
LCLC-103H Growth inhibition assay IC50 = 33.25 nM SANGER
NCI-H510A Growth inhibition assay IC50 = 33.27 nM SANGER
BC-1 Growth inhibition assay IC50 = 33.77 nM SANGER
SK-CO-1 Growth inhibition assay IC50 = 34.01 nM SANGER
A673 Growth inhibition assay IC50 = 34.17 nM SANGER
VM-CUB-1 Growth inhibition assay IC50 = 34.69 nM SANGER
HH Growth inhibition assay IC50 = 35.06 nM SANGER
CAL-27 Growth inhibition assay IC50 = 35.16 nM SANGER
NEC8 Growth inhibition assay IC50 = 35.37 nM SANGER
BxPC-3 Growth inhibition assay IC50 = 36.91 nM SANGER
SNB75 Growth inhibition assay IC50 = 37.24 nM SANGER
NB13 Growth inhibition assay IC50 = 38.23 nM SANGER
SK-OV-3 Growth inhibition assay IC50 = 38.74 nM SANGER
ME-180 Growth inhibition assay IC50 = 38.8 nM SANGER
JiyoyeP-2003 Growth inhibition assay IC50 = 39.38 nM SANGER
LU-134-A Growth inhibition assay IC50 = 40.02 nM SANGER
LS-123 Growth inhibition assay IC50 = 40.28 nM SANGER
COLO-800 Growth inhibition assay IC50 = 40.56 nM SANGER
LB831-BLC Growth inhibition assay IC50 = 41.85 nM SANGER
NCI-H747 Growth inhibition assay IC50 = 42.28 nM SANGER
MZ7-mel Growth inhibition assay IC50 = 42.66 nM SANGER
GT3TKB Growth inhibition assay IC50 = 42.72 nM SANGER
23132-87 Growth inhibition assay IC50 = 43.05 nM SANGER
MOLT-16 Growth inhibition assay IC50 = 43.05 nM SANGER
PF-382 Growth inhibition assay IC50 = 44.22 nM SANGER
ES3 Growth inhibition assay IC50 = 44.6 nM SANGER
SW756 Growth inhibition assay IC50 = 45.14 nM SANGER
OAW-28 Growth inhibition assay IC50 = 45.36 nM SANGER
RPMI-8402 Growth inhibition assay IC50 = 45.93 nM SANGER
NCI-H1693 Growth inhibition assay IC50 = 46.09 nM SANGER
MS-1 Growth inhibition assay IC50 = 46.34 nM SANGER
WSU-NHL Growth inhibition assay IC50 = 50.35 nM SANGER
HCT-116 Growth inhibition assay IC50 = 50.83 nM SANGER
SF295 Growth inhibition assay IC50 = 51.12 nM SANGER
MFE-296 Growth inhibition assay IC50 = 51.35 nM SANGER
NCI-H209 Growth inhibition assay IC50 = 52.07 nM SANGER
SW962 Growth inhibition assay IC50 = 52.41 nM SANGER
CTB-1 Growth inhibition assay IC50 = 53.39 nM SANGER
EFO-21 Growth inhibition assay IC50 = 53.66 nM SANGER
A704 Growth inhibition assay IC50 = 53.78 nM SANGER
COR-L279 Growth inhibition assay IC50 = 53.91 nM SANGER
HN Growth inhibition assay IC50 = 54.09 nM SANGER
Caov-3 Growth inhibition assay IC50 = 54.13 nM SANGER
NCI-H1770 Growth inhibition assay IC50 = 55.04 nM SANGER
G-401 Growth inhibition assay IC50 = 55.16 nM SANGER
KYSE-410 Growth inhibition assay IC50 = 55.87 nM SANGER
OE33 Growth inhibition assay IC50 = 61.17 nM SANGER
NCI-H1694 Growth inhibition assay IC50 = 61.29 nM SANGER
KG-1 Growth inhibition assay IC50 = 62.2 nM SANGER
SNU-423 Growth inhibition assay IC50 = 62.48 nM SANGER
GDM-1 Growth inhibition assay IC50 = 62.54 nM SANGER
SU-DHL-1 Growth inhibition assay IC50 = 62.66 nM SANGER
LB2518-MEL Growth inhibition assay IC50 = 64.52 nM SANGER
LB996-RCC Growth inhibition assay IC50 = 65.09 nM SANGER
MOLT-4 Growth inhibition assay IC50 = 65.28 nM SANGER
J-RT3-T3-5 Growth inhibition assay IC50 = 67.18 nM SANGER
HCC1599 Growth inhibition assay IC50 = 70.22 nM SANGER
TYK-nu Growth inhibition assay IC50 = 72.64 nM SANGER
EW-18 Growth inhibition assay IC50 = 72.75 nM SANGER
LC4-1 Growth inhibition assay IC50 = 74.74 nM SANGER
COLO-680N Growth inhibition assay IC50 = 75.49 nM SANGER
MKN1 Growth inhibition assay IC50 = 78.37 nM SANGER
HCT-15 Growth inhibition assay IC50 = 82.16 nM SANGER
NCI-H1882 Growth inhibition assay IC50 = 82.45 nM SANGER
IMR-5 Growth inhibition assay IC50 = 82.96 nM SANGER
DB Growth inhibition assay IC50 = 84.4 nM SANGER
P12-ICHIKAWA Growth inhibition assay IC50 = 84.7 nM SANGER
KARPAS-422 Growth inhibition assay IC50 = 85.79 nM SANGER
SK-N-DZ Growth inhibition assay IC50 = 86.56 nM SANGER
FTC-133 Growth inhibition assay IC50 = 87.49 nM SANGER
SCC-3 Growth inhibition assay IC50 = 89.64 nM SANGER
KM12 Growth inhibition assay IC50 = 91.49 nM SANGER
OAW-42 Growth inhibition assay IC50 = 92.14 nM SANGER
GCIY Growth inhibition assay IC50 = 92.69 nM SANGER
KYSE-520 Growth inhibition assay IC50 = 92.84 nM SANGER
RPMI-8866 Growth inhibition assay IC50 = 95.23 nM SANGER
L-363 Growth inhibition assay IC50 = 95.5 nM SANGER
22RV1 Growth inhibition assay IC50 = 96.48 nM SANGER
DSH1 Growth inhibition assay IC50 = 96.5 nM SANGER
A253 Growth inhibition assay IC50 = 102.28 nM SANGER
NCI-H661 Growth inhibition assay IC50 = 104.02 nM SANGER
SK-MEL-3 Growth inhibition assay IC50 = 105.1 nM SANGER
FADU Growth inhibition assay IC50 = 105.45 nM SANGER
SJRH30 Growth inhibition assay IC50 = 106.41 nM SANGER
HCC1569 Growth inhibition assay IC50 = 109.36 nM SANGER
NCI-H526 Growth inhibition assay IC50 = 109.88 nM SANGER
BL-70 Growth inhibition assay IC50 = 110.97 nM SANGER
SW1990 Growth inhibition assay IC50 = 113.07 nM SANGER
LAMA-84 Growth inhibition assay IC50 = 115.04 nM SANGER
COLO-741 Growth inhibition assay IC50 = 120.12 nM SANGER
SCC-15 Growth inhibition assay IC50 = 121.13 nM SANGER
DBTRG-05MG Growth inhibition assay IC50 = 121.82 nM SANGER
HEC-1 Growth inhibition assay IC50 = 123.63 nM SANGER
D-283MED Growth inhibition assay IC50 = 126.98 nM SANGER
RD Growth inhibition assay IC50 = 130.11 nM SANGER
K052 Growth inhibition assay IC50 = 136.71 nM SANGER
CAL-85-1 Growth inhibition assay IC50 = 144.63 nM SANGER
NCI-H2052 Growth inhibition assay IC50 = 144.82 nM SANGER
BFTC-909 Growth inhibition assay IC50 = 145.6 nM SANGER
HuP-T3 Growth inhibition assay IC50 = 145.65 nM SANGER
NCI-H64 Growth inhibition assay IC50 = 150.93 nM SANGER
C-4-II Growth inhibition assay IC50 = 152.37 nM SANGER
KMOE-2 Growth inhibition assay IC50 = 154.93 nM SANGER
NB12 Growth inhibition assay IC50 = 155.15 nM SANGER
EM-2 Growth inhibition assay IC50 = 159.9 nM SANGER
SIMA Growth inhibition assay IC50 = 161.25 nM SANGER
SBC-1 Growth inhibition assay IC50 = 165.57 nM SANGER
KS-1 Growth inhibition assay IC50 = 166.52 nM SANGER
no-10 Growth inhibition assay IC50 = 173.76 nM SANGER
NCCIT Growth inhibition assay IC50 = 176.26 nM SANGER
RERF-LC-MS Growth inhibition assay IC50 = 176.69 nM SANGER
BT-20 Growth inhibition assay IC50 = 181.74 nM SANGER
NCI-H1623 Growth inhibition assay IC50 = 187.08 nM SANGER
TE-9 Growth inhibition assay IC50 = 189.63 nM SANGER
U-87-MG Growth inhibition assay IC50 = 190.57 nM SANGER
CAL-51 Growth inhibition assay IC50 = 191.14 nM SANGER
639-V Growth inhibition assay IC50 = 193.14 nM SANGER
SJSA-1 Growth inhibition assay IC50 = 195.01 nM SANGER
DOHH-2 Growth inhibition assay IC50 = 195.64 nM SANGER
IST-SL1 Growth inhibition assay IC50 = 197.47 nM SANGER
NCI-H1618 Growth inhibition assay IC50 = 197.56 nM SANGER
TGW Growth inhibition assay IC50 = 199.64 nM SANGER
HT-3 Growth inhibition assay IC50 = 0.20054 μM SANGER
AN3-CA Growth inhibition assay IC50 = 0.20329 μM SANGER
PC-14 Growth inhibition assay IC50 = 0.20331 μM SANGER
BHT-101 Growth inhibition assay IC50 = 0.21039 μM SANGER
NCI-H23 Growth inhibition assay IC50 = 0.21106 μM SANGER
SCC-4 Growth inhibition assay IC50 = 0.21185 μM SANGER
EGI-1 Growth inhibition assay IC50 = 0.21386 μM SANGER
Calu-1 Growth inhibition assay IC50 = 0.22003 μM SANGER
BC-3 Growth inhibition assay IC50 = 0.22065 μM SANGER
HOP-62 Growth inhibition assay IC50 = 0.22258 μM SANGER
NCI-H1793 Growth inhibition assay IC50 = 0.22363 μM SANGER
COLO-320-HSR Growth inhibition assay IC50 = 0.22408 μM SANGER
NCI-H596 Growth inhibition assay IC50 = 0.22513 μM SANGER
EHEB Growth inhibition assay IC50 = 0.22651 μM SANGER
BEN Growth inhibition assay IC50 = 0.23791 μM SANGER
MHH-PREB-1 Growth inhibition assay IC50 = 0.24804 μM SANGER
TE-6 Growth inhibition assay IC50 = 0.25035 μM SANGER
KARPAS-299 Growth inhibition assay IC50 = 0.252 μM SANGER
BOKU Growth inhibition assay IC50 = 0.25433 μM SANGER
MZ1-PC Growth inhibition assay IC50 = 0.25435 μM SANGER
IPC-298 Growth inhibition assay IC50 = 0.25477 μM SANGER
NCI-H1792 Growth inhibition assay IC50 = 0.25904 μM SANGER
KM-H2 Growth inhibition assay IC50 = 0.26068 μM SANGER
Becker Growth inhibition assay IC50 = 0.26704 μM SANGER
NCI-H446 Growth inhibition assay IC50 = 0.26911 μM SANGER
MLMA Growth inhibition assay IC50 = 0.27156 μM SANGER
JEG-3 Growth inhibition assay IC50 = 0.27669 μM SANGER
SCC-25 Growth inhibition assay IC50 = 0.28928 μM SANGER
CA46 Growth inhibition assay IC50 = 0.29339 μM SANGER
CAL-54 Growth inhibition assay IC50 = 0.29759 μM SANGER
KYSE-70 Growth inhibition assay IC50 = 0.29969 μM SANGER
LU-65 Growth inhibition assay IC50 = 0.30381 μM SANGER
OVCAR-5 Growth inhibition assay IC50 = 0.30577 μM SANGER
NCI-H2081 Growth inhibition assay IC50 = 0.31077 μM SANGER
NCI-H226 Growth inhibition assay IC50 = 0.31696 μM SANGER
A427 Growth inhibition assay IC50 = 0.32398 μM SANGER
CPC-N Growth inhibition assay IC50 = 0.329 μM SANGER
SW13 Growth inhibition assay IC50 = 0.33037 μM SANGER
K-562 Growth inhibition assay IC50 = 0.33298 μM SANGER
NCI-N87 Growth inhibition assay IC50 = 0.33304 μM SANGER
U-698-M Growth inhibition assay IC50 = 0.34453 μM SANGER
IM-9 Growth inhibition assay IC50 = 0.34691 μM SANGER
NCI-H748 Growth inhibition assay IC50 = 0.35458 μM SANGER
UACC-257 Growth inhibition assay IC50 = 0.36412 μM SANGER
HT-1376 Growth inhibition assay IC50 = 0.36895 μM SANGER
GAK Growth inhibition assay IC50 = 0.37294 μM SANGER
NCI-H82 Growth inhibition assay IC50 = 0.37297 μM SANGER
NCI-H1304 Growth inhibition assay IC50 = 0.38454 μM SANGER
MHH-NB-11 Growth inhibition assay IC50 = 0.38597 μM SANGER
CAMA-1 Growth inhibition assay IC50 = 0.3958 μM SANGER
GCT Growth inhibition assay IC50 = 0.4051 μM SANGER
HPAF-II Growth inhibition assay IC50 = 0.42847 μM SANGER
Raji Growth inhibition assay IC50 = 0.43145 μM SANGER
EW-11 Growth inhibition assay IC50 = 0.43352 μM SANGER
SW1573 Growth inhibition assay IC50 = 0.45733 μM SANGER
KLE Growth inhibition assay IC50 = 0.45942 μM SANGER
NCI-H69 Growth inhibition assay IC50 = 0.45948 μM SANGER
MDA-MB-361 Growth inhibition assay IC50 = 0.46064 μM SANGER
SW48 Growth inhibition assay IC50 = 0.46259 μM SANGER
SK-MM-2 Growth inhibition assay IC50 = 0.47912 μM SANGER
MC116 Growth inhibition assay IC50 = 0.48166 μM SANGER
NB1 Growth inhibition assay IC50 = 0.48753 μM SANGER
NCI-H1155 Growth inhibition assay IC50 = 0.48828 μM SANGER
SN12C Growth inhibition assay IC50 = 0.49734 μM SANGER
NCI-H838 Growth inhibition assay IC50 = 0.49875 μM SANGER
SW1463 Growth inhibition assay IC50 = 0.51017 μM SANGER
NCI-H1648 Growth inhibition assay IC50 = 0.51081 μM SANGER
M14 Growth inhibition assay IC50 = 0.51466 μM SANGER
T98G Growth inhibition assay IC50 = 0.53948 μM SANGER
CaR-1 Growth inhibition assay IC50 = 0.55122 μM SANGER
NCI-H650 Growth inhibition assay IC50 = 0.56569 μM SANGER
HuH-7 Growth inhibition assay IC50 = 0.56861 μM SANGER
Daudi Growth inhibition assay IC50 = 0.56949 μM SANGER
CAL-120 Growth inhibition assay IC50 = 0.57588 μM SANGER
EW-3 Growth inhibition assay IC50 = 0.57956 μM SANGER
OMC-1 Growth inhibition assay IC50 = 0.58333 μM SANGER
U-266 Growth inhibition assay IC50 = 0.60794 μM SANGER
OVCAR-4 Growth inhibition assay IC50 = 0.62523 μM SANGER
RCC10RGB Growth inhibition assay IC50 = 0.63374 μM SANGER
NCI-H2141 Growth inhibition assay IC50 = 0.64404 μM SANGER
Ramos-2G6-4C10 Growth inhibition assay IC50 = 0.66087 μM SANGER
THP-1 Growth inhibition assay IC50 = 0.6642 μM SANGER
RCM-1 Growth inhibition assay IC50 = 0.66478 μM SANGER
K5 Growth inhibition assay IC50 = 0.68269 μM SANGER
MPP-89 Growth inhibition assay IC50 = 0.69228 μM SANGER
ChaGo-K-1 Growth inhibition assay IC50 = 0.6956 μM SANGER
OE19 Growth inhibition assay IC50 = 0.70216 μM SANGER
NCI-H1755 Growth inhibition assay IC50 = 0.71816 μM SANGER
KNS-42 Growth inhibition assay IC50 = 0.73582 μM SANGER
no-11 Growth inhibition assay IC50 = 0.73668 μM SANGER
IST-MES1 Growth inhibition assay IC50 = 0.77354 μM SANGER
NCI-H2347 Growth inhibition assay IC50 = 0.79201 μM SANGER
SKG-IIIa Growth inhibition assay IC50 = 0.80972 μM SANGER
UACC-62 Growth inhibition assay IC50 = 0.8126 μM SANGER
SNU-387 Growth inhibition assay IC50 = 0.82744 μM SANGER
LS-513 Growth inhibition assay IC50 = 0.88761 μM SANGER
NCI-H719 Growth inhibition assay IC50 = 0.89157 μM SANGER
HOP-92 Growth inhibition assay IC50 = 0.95075 μM SANGER
CAS-1 Growth inhibition assay IC50 = 0.95508 μM SANGER
HTC-C3 Growth inhibition assay IC50 = 0.9965 μM SANGER
D-392MG Growth inhibition assay IC50 = 1.02288 μM SANGER
MHH-CALL-2 Growth inhibition assay IC50 = 1.02319 μM SANGER
DMS-53 Growth inhibition assay IC50 = 1.03815 μM SANGER
TGBC24TKB Growth inhibition assay IC50 = 1.04183 μM SANGER
NCI-H1417 Growth inhibition assay IC50 = 1.07075 μM SANGER
OVCAR-3 Growth inhibition assay IC50 = 1.0739 μM SANGER
RXF393 Growth inhibition assay IC50 = 1.1432 μM SANGER
MKN28 Growth inhibition assay IC50 = 1.15124 μM SANGER
MSTO-211H Growth inhibition assay IC50 = 1.15257 μM SANGER
NCI-H2126 Growth inhibition assay IC50 = 1.15799 μM SANGER
TCCSUP Growth inhibition assay IC50 = 1.16785 μM SANGER
TE-12 Growth inhibition assay IC50 = 1.17366 μM SANGER
NCI-H1581 Growth inhibition assay IC50 = 1.17372 μM SANGER
GOTO Growth inhibition assay IC50 = 1.20277 μM SANGER
NCI-H28 Growth inhibition assay IC50 = 1.2149 μM SANGER
KNS-81-FD Growth inhibition assay IC50 = 1.23463 μM SANGER
YT Growth inhibition assay IC50 = 1.28559 μM SANGER
NB5 Growth inhibition assay IC50 = 1.32585 μM SANGER
U-118-MG Growth inhibition assay IC50 = 1.35159 μM SANGER
LS-1034 Growth inhibition assay IC50 = 1.3845 μM SANGER
PANC-08-13 Growth inhibition assay IC50 = 1.39613 μM SANGER
COLO-205 Growth inhibition assay IC50 = 1.47181 μM SANGER
KURAMOCHI Growth inhibition assay IC50 = 1.49739 μM SANGER
SNU-C2B Growth inhibition assay IC50 = 1.54777 μM SANGER
HDLM-2 Growth inhibition assay IC50 = 1.63327 μM SANGER
PFSK-1 Growth inhibition assay IC50 = 1.64794 μM SANGER
SW1088 Growth inhibition assay IC50 = 1.66167 μM SANGER
LB373-MEL-D Growth inhibition assay IC50 = 1.66495 μM SANGER
HT-1197 Growth inhibition assay IC50 = 1.76425 μM SANGER
MMAC-SF Growth inhibition assay IC50 = 1.7766 μM SANGER
T-24 Growth inhibition assay IC50 = 2.07629 μM SANGER
LK-2 Growth inhibition assay IC50 = 2.08563 μM SANGER
5637 Growth inhibition assay IC50 = 2.10298 μM SANGER
GI-ME-N Growth inhibition assay IC50 = 2.10851 μM SANGER
NCI-H2196 Growth inhibition assay IC50 = 2.31034 μM SANGER
KOSC-2 Growth inhibition assay IC50 = 2.35338 μM SANGER
MN-60 Growth inhibition assay IC50 = 2.43457 μM SANGER
AsPC-1 Growth inhibition assay IC50 = 2.50301 μM SANGER
MDA-MB-175-VII Growth inhibition assay IC50 = 2.51493 μM SANGER
DG-75 Growth inhibition assay IC50 = 2.5612 μM SANGER
LNCaP-Clone-FGC Growth inhibition assay IC50 = 2.65415 μM SANGER
SCLC-21H Growth inhibition assay IC50 = 2.77414 μM SANGER
EFE-184 Growth inhibition assay IC50 = 2.79042 μM SANGER
HCC2157 Growth inhibition assay IC50 = 2.80678 μM SANGER
NCI-H1573 Growth inhibition assay IC50 = 2.80723 μM SANGER
PC-3 Growth inhibition assay IC50 = 2.83163 μM SANGER
KY821 Growth inhibition assay IC50 = 2.8814 μM SANGER
ECC4 Growth inhibition assay IC50 = 2.92765 μM SANGER
SK-N-AS Growth inhibition assay IC50 = 2.96758 μM SANGER
NB6 Growth inhibition assay IC50 = 3.2819 μM SANGER
KMS-12-PE Growth inhibition assay IC50 = 3.55998 μM SANGER
NCI-H2171 Growth inhibition assay IC50 = 3.76535 μM SANGER
TE-11 Growth inhibition assay IC50 = 4.09997 μM SANGER
DMS-153 Growth inhibition assay IC50 = 4.10246 μM SANGER
RVH-421 Growth inhibition assay IC50 = 4.11559 μM SANGER
RO82-W-1 Growth inhibition assay IC50 = 4.42356 μM SANGER
TE-1 Growth inhibition assay IC50 = 5.86741 μM SANGER
MFE-280 Growth inhibition assay IC50 = 5.90388 μM SANGER
HT Growth inhibition assay IC50 = 5.93153 μM SANGER
NCI-H1963 Growth inhibition assay IC50 = 6.26713 μM SANGER
S-117 Growth inhibition assay IC50 = 6.30327 μM SANGER
TGBC1TKB Growth inhibition assay IC50 = 6.51712 μM SANGER
NCI-H1522 Growth inhibition assay IC50 = 6.53336 μM SANGER
TE-441-T Growth inhibition assay IC50 = 6.5501 μM SANGER
UACC-893 Growth inhibition assay IC50 = 6.55203 μM SANGER
SHP-77 Growth inhibition assay IC50 = 6.85463 μM SANGER
TALL-1 Growth inhibition assay IC50 = 7.00001 μM SANGER
T47D Growth inhibition assay IC50 = 7.00094 μM SANGER
Capan-2 Growth inhibition assay IC50 = 7.09987 μM SANGER
SK-MEL-2 Growth inhibition assay IC50 = 7.13094 μM SANGER
NCI-H1092 Growth inhibition assay IC50 = 7.15535 μM SANGER
LP-1 Growth inhibition assay IC50 = 7.30969 μM SANGER
NCI-H889 Growth inhibition assay IC50 = 7.57024 μM SANGER
NCI-H2452 Growth inhibition assay IC50 = 7.63456 μM SANGER
UMC-11 Growth inhibition assay IC50 = 8.35939 μM SANGER
LU-165 Growth inhibition assay IC50 = 8.41085 μM SANGER
Mewo Growth inhibition assay IC50 = 8.43715 μM SANGER
C32 Growth inhibition assay IC50 = 8.43927 μM SANGER
DV-90 Growth inhibition assay IC50 = 8.45559 μM SANGER
SW1417 Growth inhibition assay IC50 = 8.63434 μM SANGER
NCI-H187 Growth inhibition assay IC50 = 8.85234 μM SANGER
LU-99A Growth inhibition assay IC50 = 9.13742 μM SANGER
DMS-79 Growth inhibition assay IC50 = 9.4013 μM SANGER
MDA-MB-415 Growth inhibition assay IC50 = 9.95336 μM SANGER
HCC1954 Growth inhibition assay IC50 = 9.97404 μM SANGER
EB-3 Growth inhibition assay IC50 = 11.1641 μM SANGER
CW-2 Growth inhibition assay IC50 = 11.2237 μM SANGER
COR-L88 Growth inhibition assay IC50 = 11.4887 μM SANGER
CP50-MEL-B Growth inhibition assay IC50 = 11.567 μM SANGER
LN-405 Growth inhibition assay IC50 = 11.8448 μM SANGER
EVSA-T Growth inhibition assay IC50 = 11.9609 μM SANGER
HCC70 Growth inhibition assay IC50 = 12.0511 μM SANGER
UACC-812 Growth inhibition assay IC50 = 13.3687 μM SANGER
LC-1F Growth inhibition assay IC50 = 13.4575 μM SANGER
HCC1419 Growth inhibition assay IC50 = 13.5715 μM SANGER
C2BBe1 Growth inhibition assay IC50 = 13.6612 μM SANGER
COLO-678 Growth inhibition assay IC50 = 13.7484 μM SANGER
RT4 Growth inhibition assay IC50 = 13.8428 μM SANGER
NCI-H524 Growth inhibition assay IC50 = 15.3769 μM SANGER
HCC1143 Growth inhibition assay IC50 = 16.3541 μM SANGER
HT55 Growth inhibition assay IC50 = 16.4103 μM SANGER
CAL-39 Growth inhibition assay IC50 = 16.6227 μM SANGER
KU-19-19 Growth inhibition assay IC50 = 16.8123 μM SANGER
LB771-HNC Growth inhibition assay IC50 = 16.9876 μM SANGER
OPM-2 Growth inhibition assay IC50 = 17.6337 μM SANGER
CAKI-1 Growth inhibition assay IC50 = 18.0406 μM SANGER
KP-N-YN Growth inhibition assay IC50 = 18.8885 μM SANGER
SW948 Growth inhibition assay IC50 = 20.4975 μM SANGER
SK-MEL-1 Growth inhibition assay IC50 = 20.6083 μM SANGER
NCI-H1563 Growth inhibition assay IC50 = 21.5347 μM SANGER
GMS-10 Growth inhibition assay IC50 = 21.6061 μM SANGER
MDA-MB-453 Growth inhibition assay IC50 = 22.2184 μM SANGER
PLC-PRF-5 Growth inhibition assay IC50 = 22.8813 μM SANGER
EFM-19 Growth inhibition assay IC50 = 24.2029 μM SANGER
SK-N-FI Growth inhibition assay IC50 = 25.1429 μM SANGER
Saos-2 Growth inhibition assay IC50 = 26.765 μM SANGER
KARPAS-45 Growth inhibition assay IC50 = 27.5648 μM SANGER
EKVX Growth inhibition assay IC50 = 27.7875 μM SANGER
KINGS-1 Growth inhibition assay IC50 = 30.879 μM SANGER
NCI-H2227 Growth inhibition assay IC50 = 31.2813 μM SANGER
D-542MG Growth inhibition assay IC50 = 32.2968 μM SANGER
D-263MG Growth inhibition assay IC50 = 33.5726 μM SANGER
A498 Growth inhibition assay IC50 = 38.4491 μM SANGER
MDA-MB-157 Growth inhibition assay IC50 = 38.5533 μM SANGER
RMG-I Growth inhibition assay IC50 = 42.9009 μM SANGER
COLO-792 Growth inhibition assay IC50 = 43.2931 μM SANGER
SK-MEL-24 Growth inhibition assay IC50 = 43.4294 μM SANGER
SNU-475 Growth inhibition assay IC50 = 44.5002 μM SANGER
HuO-3N1 Growth inhibition assay IC50 = 46.3321 μM SANGER
LAN-6 Growth inhibition assay IC50 = 46.6441 μM SANGER
NCI-H720 Growth inhibition assay IC50 = 46.7503 μM SANGER
BB49-HNC Growth inhibition assay IC50 = 47.6209 μM SANGER
TT Growth inhibition assay IC50 = 49.8459 μM SANGER
Ramos Cytotoxicity assay 72 hrs EC50 = 0.00003 μM 27032331
MDA-MB-231 Antiproliferative assay GI50 = 0.000251 μM 29301085
Colo-357 Cytotoxicity assay IC50 = 0.00036 μM 20930123
SW620 Antiproliferative assay GI50 = 0.00084 μM 29301085
BV173 Cytotoxicity assay 3 days IC50 = 0.001 μM 21711054
PANC1 Cytotoxicity assay IC50 = 0.001 μM 20930123
RT112 Cytotoxicity assay EC50 = 0.0014 μM 24471998
A2780 Growth inhibition assay IC50 = 0.0015 μM 17602464
T3M4 Cytotoxicity assay IC50 = 0.0015 μM 20930123
NCI-H23 Cytotoxicity assay 5 days GI50 = 0.002 μM 19929004
H460 Antiproliferative assay GI50 = 0.002085 μM 29301085
OVCAR8 Antiproliferative assay 72 hrs IC50 = 0.0026 μM 18469809
PC3 Antiproliferative assay 72 hrs IC50 = 0.0026 μM 18469809
A2780/E6 Antiproliferative assay 72 hrs IC50 = 0.0026 μM 18469809
Patu-T Cytotoxicity assay IC50 = 0.0028 μM 20930123
HCT15 Cytotoxicity assay 5 days GI50 = 0.003 μM 19929004
HT-29 Cytotoxicity assay IC50 = 0.003 μM 11728191
OVCAR8 Antiproliferative assay 72 hrs IC50 = 0.003 μM 20873740
C3 Antiproliferative assay 72 hrs IC50 = 0.003 μM 20873740
Patu-S Cytotoxicity assay IC50 = 0.0032 μM 20930123
Patu-02 Cytotoxicity assay IC50 = 0.0034 μM 20930123
DAN-G Cytotoxicity assay IC50 = 0.0034 μM 20930123
DU145 Antiproliferative assay IC50 = 0.0035 μM 17887663
BxPC3 Growth inhibition assay 48 hrs GI50 = 0.00364 μM 23094992
A549 Cytotoxicity assay 24 hrs IC50 = 0.0039 μM 25874330
A549 Cytotoxicity assay 48 hrs IC50 = 0.0039 μM 25874330
MRC5 Cytotoxicity assay 48 hrs IC50 = 0.0039 μM 25874330
T24 Cytotoxicity assay 48 hrs IC50 = 0.0039 μM 25874330
T24 Cytotoxicity assay 24 hrs IC50 = 0.0039 μM 25874330
MRC5 Cytotoxicity assay 24 hrs IC50 = 0.0039 μM 25874330
BT549 Cytotoxicity assay 5 days GI50 = 0.004 μM 19929004
MCF7 Cytotoxicity assay 24 hrs LD50 = 0.004 μM 24786915
Aspc-1 Cytotoxicity assay IC50 = 0.004 μM 20930123
HCT116 Cytotoxicity assay IC50 = 0.005 μM 19691349
MES-SA Cytotoxicity assay 3 days IC50 = 0.005 μM 21711054
HCT116 Cytotoxicity assay 24 hrs LD50 = 0.005 μM 24786915
RAW264.7 Cytotoxicity assay 24 hrs LD50 = 0.005 μM 24786915
PC3 Cytotoxicity assay 5 days GI50 = 0.006 μM 19929004
HCT116 Antiproliferative assay 72 hrs IC50 = 0.006 μM 20873740
K562 Cytotoxicity assay 3 days IC50 = 0.006 μM 21711054
CT26 Cytotoxicity assay 3 days IC50 = 0.006 μM 21711054
BxPC3 Growth inhibition assay 96 hrs IC50 = 0.006 μM 29356532
MRC5 Cytotoxicity assay 48 hrs IC50 = 0.0063 μM 25874330
A549 Cytotoxicity assay 48 hrs IC50 = 0.0068 μM 25874330
MRC5 Cytotoxicity assay 24 hrs IC50 = 0.0068 μM 25874330
T24 Cytotoxicity assay 48 hrs IC50 = 0.0069 μM 25874330
EL4 Cytotoxicity assay 3 days IC50 = 0.007 μM 21711054
L1210 Cytotoxicity assay 3 days IC50 = 0.007 μM 21711054
MCF7 Cytotoxicity assay 2 days IC50 = 0.0072 μM 24341356
NCI-H460 Cytotoxicity assay IC50 = 0.0078 μM 11728191
BT549 Cytotoxicity assay 3 days IC50 = 0.008 μM 21711054
MOLT4 Cytotoxicity assay 24 hrs LD50 = 0.008 μM 24786915
BxPC3 Growth inhibition assay 48 hrs LC50 = 0.00871 μM 23094992
DMS53 Antiproliferative assay 72 hrs IC50 = 0.009 μM 22861499
MES-SA Cytotoxicity assay IC50 = 0.0092 μM 11728191
HCT116 Antiproliferative assay 72 hrs IC50 = 0.0097 μM 18469809
HCT15 Antiproliferative assay 72 hrs IC50 = 0.0099 μM 18469809
HeLa Cytotoxicity assay 4 days IC50 = 0.0099 μM 24341356
H460 Growth inhibition assay IC50 = 0.01 μM 17602464
MCF7 Antitumor assay 48 hrs GI50 = 0.01 μM 18588281
SF268 Antiproliferative assay 72 hrs IC50 = 0.01 μM 20873740
HCT15 Antiproliferative assay 72 hrs IC50 = 0.01 μM 20873740
BxPC3 Cytotoxicity assay 5 days EC50 = 0.01 μM 24867590
SF268 Antiproliferative assay 72 hrs IC50 = 0.0103 μM 18469809
MDA-MB-231 Antiproliferative assay IC50 = 0.0114 μM 17887663
Jurkat Cytotoxicity assay 24 hrs LD50 = 0.012 μM 24786915
H292 Growth inhibition assay IC50 = 0.013 μM 17602464
L1210 Cytotoxicity assay 2 days IC50 = 0.013 μM 24341356
L1210 Cytotoxicity assay 48 hrs IC50 = 0.013 μM 24471998
SW480 Antiproliferative assay 72 hrs IC50 = 0.0136 μM 18469809
A549 Growth inhibition assay IC50 = 0.014 μM 17602464
A2780 Growth inhibition assay IC50 = 0.015 μM 17602464
SW1573 Growth inhibition assay IC50 = 0.016 μM 17602464
A2780 Antiproliferative assay 72 hrs IC50 = 0.0166 μM 18469809
T24 Cytotoxicity assay 24 hrs IC50 = 0.017 μM 25874330
T24 Cytotoxicity assay 24 hrs IC50 = 0.018 μM 25874330
P388D1 Cytotoxicity assay 3 days IC50 = 0.019 μM 21711054
Capan1 Growth inhibition assay 96 hrs IC50 = 0.019 μM 29356532
SF539 Antiproliferative assay 72 hrs IC50 = 0.0198 μM 18469809
SF539 Antiproliferative assay 72 hrs IC50 = 0.02 μM 20873740
A549 Antiproliferative assay 72 hrs IC50 = 0.02 μM 22861499
CCRF-CEM Cytotoxicity assay 72 hrs IC50 = 0.02 μM 28221790
MRC5 Cytotoxicity assay 24 hrs IC50 = 0.0216 μM 25874330
CEM-DNR-bulk Cytotoxicity assay 3 days IC50 = 0.022 μM 21711054
Jurkat Cytotoxicity assay 72 hrs EC50 = 0.023 μM 27032331
HeLa Cytotoxicity assay 24 hrs LD50 = 0.023 μM 24786915
MDA-MB-231 Antiproliferative assay 48 hrs IC50 = 0.025 μM 25350923
U373-MAGI Antiviral assay 2 hrs EC50 = 0.0275 μM 24120088
A549 Cytotoxicity assay 24 hrs IC50 = 0.029 μM 25874330
HT29 Antitumor assay 48 hrs GI50 = 0.03 μM 18588281
Jurkat Antiproliferative assay 72 hrs IC50 = 0.03 μM 20873740
HCT116 Cytotoxicity assay 72 hrs IC50 = 0.03 μM 28221790
MDA-MB-231 Growth inhibition assay 72 hrs IC50 = 0.03 μM 29253340
HCT116 Growth inhibition assay 72 hrs IC50 = 0.03 μM 29253340
A2780 Antiproliferative assay 72 hrs IC50 = 0.035 μM 20873740
DU-145 Cytotoxicity assay IC50 = 0.0356 μM 11728191
MIAPaCa2 Growth inhibition assay 48 hrs GI50 = 0.03583 μM 23094992
MDA-MB-231 Antiproliferative assay 48 hrs IC50 = 0.0364 μM 29795767
PC3 Cytotoxicity assay IC50 = 0.04 μM 19691349
Jurkat Antiproliferative assay 72 hrs IC50 = 0.0453 μM 18469809
HeLa Cytotoxicity assay 72 hrs IC50 = 0.05 μM 22944119
K562 Cytotoxicity assay 48 hrs IC50 = 0.05 μM 24631359
A549 Cytotoxicity assay 72 hrs IC50 = 0.05 μM 28221790
K562-TAX Cytotoxicity assay 72 hrs IC50 = 0.05 μM 28221790
COLO205 Antiproliferative assay 72 hrs IC50 = 0.0514 μM 18469809
MCF7 Cytotoxicity assay 72 hrs IC50 = 0.06 μM 22944119
MIAPaCa2 Cytotoxicity assay 72 hrs IC50 = 0.06 μM 22944119
PC3 Cytotoxicity assay 72 hrs EC50 = 0.065 μM 27032331
CEM Cytotoxicity assay 3 days IC50 = 0.069 μM 24341356
HPAC Cytotoxicity assay 3 days IC50 = 0.073 μM 21711054
MCF7 Antiproliferative assay 72 hrs IC50 = 0.08 μM 20873740
MCF7 Antiproliferative assay 72 hrs IC50 = 0.0803 μM 18469809
CEM Cytotoxicity assay 72 hrs IC50 = 0.086 μM 24471998
A549 Cytotoxicity assay IC50 = 0.09 μM 19691349
U2OS Antiproliferative assay 72 hrs IC50 = 0.0907 μM 18469809
HuH7 Cytotoxicity assay CC50 = 0.1 μM 20580554
K562 Cytotoxicity assay 72 hrs IC50 = 0.1 μM 28221790
CEM-DNR-bulk Cytotoxicity assay 72 hrs IC50 = 0.1 μM 28221790
MIAPaCa2 Growth inhibition assay 48 hrs LC50 = 0.1 μM 23094992
H460 Growth inhibition assay IC50 = 0.103 μM 17602464
RT112 Cytotoxicity assay EC50 = 0.1049 μM 24471998
PANC1 Cytotoxicity assay 48 hrs IC50 = 0.11 μM 22342146
MIAPaCa2 Cytotoxicity assay 72 hrs IC50 = 0.11 μM 29328656
MIAPaCa2 Antiproliferative assay 70 hrs IC50 = 0.12 μM 29471119
CEM Growth inhibition assay IC50 = 0.13 μM 17602464
MCF7 Cytotoxicity assay 3 days IC50 = 0.149 μM 21711054
MCF7 Cytotoxicity assay 72 hrs IC50 = 0.15 μM 26025875
CaCo2 Antitumor assay 48 hrs GI50 = 0.18 μM 18588281
U2OS Antiproliferative assay 72 hrs IC50 = 0.18 μM 20873740
U2OS Cytotoxicity assay 72 hrs IC50 = 0.18 μM 28221790
MDA-MB-231 Cytotoxicity assay 24 hrs IC50 = 0.19 μM 25703296
H292 Growth inhibition assay IC50 = 0.21 μM 17602464
A549 Growth inhibition assay IC50 = 0.225 μM 17602464
NCI-H460 Cytotoxicity assay 48 hrs IC50 = 0.23 μM 22342146
MDA-MB-231 Cytotoxicity assay 3 days IC50 = 0.245 μM 21711054
SW1573 Growth inhibition assay IC50 = 0.275 μM 17602464
A2780 Cytotoxicity assay 72 hrs IC50 = 0.31 μM 19362474
K562 Antitumor assay 48 hrs GI50 = 0.32 μM 18588281
HCT116 Cytotoxicity assay 48 hrs IC50 = 0.32 μM 22342146
CFPAC-1 Cytotoxicity assay 96 hrs IC50 = 0.35 μM 24631359
PANC1 Cytotoxicity assay 72 hrs IC50 = 0.4 μM 29656202
HCT116 Cytotoxicity assay 72 hrs IC50 = 0.41 μM 28221790
CFPAC-1 Cytotoxicity assay 72 hrs IC50 = 0.47 μM 24631359
ACHN Cytotoxicity assay 48 hrs IC50 = 0.48 μM 22342146
HCT116-E6 Antiproliferative assay 72 hrs IC50 = 0.5 μM 20873740
C6 Cytotoxicity assay 3 days IC50 = 0.504 μM 21711054
LNCAP Cytotoxicity assay 3 days IC50 = 0.512 μM 21711054
Calu1 Cytotoxicity assay 48 hrs IC50 = 0.52 μM 22342146
HT-29 Cytotoxicity assay 72 hrs IC50 = 0.52 μM 26025875
MCF7 Cytotoxicity assay 72 hrs IC50 = 0.57 μM 28075592
K562 Antiproliferative assay 72 hrs IC50 = 0.6 μM 20873740
MIAPaCa2 Cytotoxicity assay 24 hrs IC50 = 0.6 μM 25703296
MDA-MB-231 Cytotoxicity assay 72 hrs IC50 = 0.65 μM 26025875
BxPC3 Cytotoxicity assay 72 hrs IC50 = 0.67 μM 24471998
K562 Cytotoxicity assay 3 days IC50 = 0.718 μM 21711054
K562 Antiproliferative assay 72 hrs IC50 = 0.7459 μM 18469809
Bel7402 Cytotoxicity assay 72 hrs IC50 = 0.84 μM 19362474
HCT116/E6 Antiproliferative assay 72 hrs IC50 = 0.8965 μM 18469809
HeLa Cytotoxicity assay 96 hrs IC50 = 0.9 μM 24631359
CEM Growth inhibition assay IC50 = 1 μM 17602464
HB-1 Antiviral assay 24 hrs EC50 = 1 μM 20580554
MIAPaCa2 Cytotoxicity assay 72 hrs IC50 = 1.04 μM 24471998
SK-N-AS Cytotoxicity assay 3 days IC50 = 1.1 μM 21711054
SW1990 Cytotoxicity assay 72 hrs IC50 = 1.2 μM 19362474
A549 Cytotoxicity assay 72 hrs IC50 = 1.4 μM 19362474
HepG2 Function assay Km = 1.4 μM 17101674
BL21(DE3) Function assay Km = 1.43 μM 23230131
U87MG Cytotoxicity assay 3 days IC50 = 1.49 μM 21711054
BL21(DE3) Function assay Km = 1.52 μM 23230131
HT-29 Cytotoxicity assay 3 days IC50 = 1.53 μM 21711054
SW1990 Cytotoxicity assay IC50 = 1.6 μM 24195466
Capan2 Cytotoxicity assay 72 hrs IC50 = 1.7 μM 19362474
SW480 Antiproliferative assay 72 hrs IC50 = 1.7 μM 20873740
PANC1 Cytotoxicity assay 72 hrs IC50 = 1.7 μM 29656202
HCT8 Cytotoxicity assay 72 hrs IC50 = 1.74 μM 19362474
BL21(DE3) Function assay Km = 1.75 μM 23230131
HT-29 Cytotoxicity assay 48 hrs IC50 = 1.95 μM 23968824
MIAPaCa2 Cytotoxicity assay 5 days EC50 = 2 μM 24867590
BL21(DE3) Function assay 1 min Km = 2.15 μM 23230131
SW1990 Cytotoxicity assay IC50 = 2.2 μM 25105722
SW1990 Cytotoxicity assay 48 hrs IC50 = 2.3 μM 27966950
NCI-H146 Cytotoxicity assay 3 days IC50 = 2.78 μM 21711054
BxPC3 Cytotoxicity assay 72 hrs IC50 = 2.9 μM 19362474
p53 deficient COLO205 Antiproliferative assay 72 hrs IC50 = 3 μM 20873740
MiaPaCa Cytotoxicity assay 6 days IC50 = 3 μM 23360104
COLO205 Cytotoxicity assay 48 hrs IC50 = 3.24 μM 23968824
MCF7 Cytotoxicity assay 72 hrs IC50 = 3.28 μM 19362474
MIAPaCa2 Cytotoxicity assay 72 hrs IC50 = 3.3 μM 29328656
HeLa Cytotoxicity assay 24 hrs IC50 = 3.3 μM 25703296
FTC-133 Cytotoxicity assay 24 hrs IC50 = 3.36 μM 24436994
BxPC3 Growth inhibition assay 48 hrs GI50 = 3.64 μM 22512908
COLO320DM Cytotoxicity assay 48 hrs IC50 = 3.92 μM 23968824
HeLa Cytotoxicity assay 3 days IC50 = 4.12 μM 21711054
8305C Cytotoxicity assay 24 hrs IC50 = 4.53 μM 24436994
PANC1 Cytotoxicity assay 72 hrs IC50 = 5.6 μM 19362474
PANC1 Growth inhibition assay 72 hrs GI50 = 5.8 μM 28495081
SK-MEL-2 Cytotoxicity assay 3 days IC50 = 7.11 μM 21711054
CEM Cytotoxicity assay 3 days IC50 = 7.6 μM 24341356
SW1573 Cytotoxicity assay 72 hrs IC50 = 8.3 μM 17419604
BxPC3 Growth inhibition assay 48 hrs LC50 = 8.71 μM 22512908
MCF7 Cytotoxicity assay 72 hrs IC50 = 8.9 μM 28075592
BJ Cytotoxicity assay 3 days IC50 = 9.88 μM 21711054
HeLa Cytotoxicity assay 72 hrs IC50 = 10 μM 24631359
B16-F10-Luc-G5 Antiproliferative assay 24 hrs IC50 = 11 μM 27349332
HCT15 Cytotoxicity assay IC50 = 11.8 μM 18186604
A549 Cytotoxicity assay 72 hrs IC50 = 13.1 μM 17419604
HCT116 Cytotoxicity assay IC50 = 14.3 μM 18186604
MiaPaCa Cytotoxicity assay 72 hrs IC50 = 17.1 μM 23489626
AG6000 Growth inhibition assay IC50 = 20 μM 17602464
AG6000 Growth inhibition assay IC50 = 20 μM 17602464
BxPC3 Antiproliferative assay 72 hrs IC50 = 20.2 μM 28576633
CV1 Cytotoxicity assay 72 hrs IC50 = 21.9 μM 23489626
AsPC1 Antiproliferative assay 72 hrs IC50 = 26.8 μM 28576633
PANC1 Antiproliferative assay 72 hrs IC50 = 30.4 μM 28576633
MIAPaCa2 Growth inhibition assay 48 hrs GI50 = 35.83 μM 22512908
Click to View More Cell Line Experimental Data

Biological Activity

Description Gemcitabine HCl is a DNA synthesis inhibitor with IC50 of 50 nM, 40 nM, 18 nM and 12 nM in PANC1, MIAPaCa2, BxPC3 and Capan2 cells, respectively.
Features Gemcitabine has been used to treat pancreatic cancer and has demonstrated effective anti-tumor activity.
Targets
DNA synthesis (Capan2 cells) [1] DNA synthesis (BxPC3 cells) [1] DNA synthesis (MIAPaCa2 cells) [1] DNA synthesis (PANC1 cells) [1]
12 nM 18 nM 40 nM 50 nM
In vitro
In vitro Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Treatment of BxPC-3 cells with low dose Gemcitabine for 48 hours results in a dose-dependent increase in NF-κB binding. In contrast, NF-κB DNA binding is decreased in BxPC-3 cells treated with the higher Gemcitabine doses for 48 h; however, 24-h treatment with these higher doses increases NF-κB binding in BxPC-3 cells [2]
Cell Research Cell lines BxPC-3, MIA PaCa-2, and PANC-1 cells
Concentrations 0.2 μM
Incubation Time 24 hours or 48 hours
Method BxPC-3, MIA PaCa-2, and PANC-1 cells are seeded in a 96-well plate. After 24 hours, cells are treated with vehicle, DMAPT and/or Gemcitabine for an additional 24 hours or 48 hours. Apoptosis is quantified using the Cell Death Detection ELISA to detect the amount of cytoplasmic histone-associated DNA fragments and expressed relative to vehicle-treated cells.
Experimental Result Images Methods Biomarkers Images PMID
Western blot p70S6K1 / p-S6 / HIF-1α LC3-I / LC3-II pS-ERα / ERα / pERK / ERK caspase-3 / caspase-8 / caspase-9 p-JNK / JNK / p-ATF2 / p-c-Jun 27765914
Immunofluorescence BMI1 27177084
Growth inhibition assay Cell viability 27765914
In Vivo
In vivo Intratumoral NF-κB activity is significantly elevated (1.3- to 1.8-fold) in the Gemcitabine-treated mice compared to the PBS-treated mice, suggesting that Gemcitabine also induces NF-κB activation. [2]
Animal Research Animal Models Athymic nude mice with MIA PaCa-2 cells
Dosages 50 mg/kg or 100 mg/kg
Administration Administered via i.p.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06046794 Not yet recruiting Cancer Of Pancreas Institut Paoli-Calmettes February 1 2024 Not Applicable
NCT06055348 Not yet recruiting Serous Ovarian Cancer|Advanced Ovarian Cancer Biocity Biopharmaceutics Co. Ltd. October 30 2023 Phase 1|Phase 2
NCT06059001 Recruiting Metastatic Pancreatic Cancer Peptomyc S.L. August 31 2023 Phase 1
NCT05562297 Not yet recruiting Pancreatic Cancer Stage IB|Pancreatic Cancer Stage IIA|Pancreatic Cancer Stage IIB|Pancreatic Cancer Stage III Shanghai Zhongshan Hospital|Fudan University July 1 2023 Phase 2

Chemical lnformation & Solubility

Molecular Weight 299.66 Formula

C9H11F2N3O4.HCI
CAS No. 122111-03-9 SDF Download Gemcitabine HCl SDF
Smiles C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)(F)F.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 59 mg/mL

DMSO : Insoluble ( Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
What’s the difference between S1714 and S1149 and which one is better?

Answer:
They have the same biological activities. The free base(S1714) dissolves better in DMSO, and the hydrochloride (S1149) dissolves better in water.

DNA/RNA Synthesis Signaling Pathway Map

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