Home Neuronal Signaling Adrenergic Receptor antagonist Maprotiline HCl For research use only.

Maprotiline HCl

Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.

Maprotiline HCl Chemical Structure

Maprotiline HCl Chemical Structure

CAS: 10347-81-6

Selleck's Maprotiline HCl has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 100%
100

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Biological Activity

Description Maprotiline HCl is a selective noradrenalin re-uptake inhibitor, used in the treatment of depression.
Targets
Adrenergic Receptor [1]
In vitro
In vitro

Maprotiline inhibits HERG channels expressed in HEK cells with an IC50 of 5.2 μM and HERG channels expressed in oocytes with an IC50 of 24 μM. Maprotiline blocks open channels but has no significant effect on closed channels. [1] Maprotiline is atetracyclic antidepressant, which strongly inhibits the uptake of noradrenaline, though it is notable in its lack of inhibition of serotonergic uptake. Maprotiline also has markedly less pronounced alpha-adrenergic blocking activity than amitriptyline. [2] Maprotiline decreases cell viability in a concentration- and time-dependent manner in Neuro-2a cells. Maprotiline induces apoptosis and increases caspase-3 activation. Maprotiline also induces [Ca(2+)](i) increases which involves the mobilization of intracellular Ca(2+) stored in the endoplasmic reticulum. [3]
In Vivo
In vivo

Maprotiline results in significantly increases GluR1 and GluR2/3 subunit expression in the nucleus accumbens and dorsal striatum of mice as detected by immunohistochemistry; and significantly increases GluR1 and GluR2/3 expression in the hippocampus, as demonstrated by Western blot analysis. [4] Maprotiline has a potent anti-inflammatory effect in rats and this effect is linked to the peripheral and supraspinal actions of the drug. [5] Maprotiline impairs learning when administered before training, but no statistically significant effect is evident when administered after training. [6]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04200066 Withdrawn Glioblastoma|Brain Tumor University of Rochester June 1 2022 Phase 1

Chemical lnformation & Solubility

Molecular Weight 313.86 Formula

C20H23N.HCl
CAS No. 10347-81-6 SDF Download Maprotiline HCl SDF
Smiles CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 63 mg/mL ( (200.72 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 24 mg/mL

Water : Insoluble


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In vivo
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