Home Endocrinology & Hormones Estrogen/progestogen Receptor agonist Mestranol For research use only.

Mestranol

Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.

Mestranol Chemical Structure

Mestranol Chemical Structure

CAS: 72-33-3

Purity & Quality Control

Batch: S212501 Ethanol] 25 mg/mL] false] DMSO] 15 mg/mL] false] Water] Insoluble] false Purity: 99.97%
99.97

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Biological Activity

Description Mestranol is the 3-methyl ether of ethinyl estradiol, which is a potent estrogen receptor agonist and used as oral contraceptives.
Targets
Estrogen receptor [1]
In vitro
In vitro Mestranol is extensively metabolized to hydroxylated products whose bio- logical activity is less well characterized. [1]
In Vivo
In vivo Mestranol (0.2 mg/kg) results in an increased percentage of liver occupied by AHF expressing glutathione S-transferase (PGST) in rats. Mestranol administration increases the focal hepatocyte labeling index compared with the control with a trend at the lower dose and a significant difference at the higher dose. Mestranol (0.02 mg/kg and 0.2 mg/kg diet) results in a decrease in the non-focal labeling index compared with that observed for the corresponding concentration of Mestranol alone. Mestranol significantly increases the non-focal hepatic labeling index in uninitiated rats compared with that observed in rats administered the basal diet only. [1] Mestranol (50 mg/100 g b.wt.) has a significant reduction in the apparent number of alpha-2-adrenoceptors in the frontal cortex and nucleus tractus solitarius (NTS) of rat, while apparent numbers of both alpha-1 and alpha-2-adrenoceptors are depressed in the locus coeruleus. [2]

Chemical lnformation & Solubility

Molecular Weight 310.43 Formula

C21H26O2
CAS No. 72-33-3 SDF Download Mestranol SDF
Smiles CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC
Storage (From the date of receipt)

In vitro
Batch:

Ethanol : 25 mg/mL

DMSO : 15 mg/mL ( (48.32 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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