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Phenoxybenzamine HCl

Name: Phenoxybenzamine HCl
Brand: Selleck Chemicals
SKU: S2499

Synonyms: NSC 37448, NCI-c01661

Catalog No.S2499 Purity: 99.06%

Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

Phenoxybenzamine HCl Chemical Structure

CAS: 63-92-3

Purity & Quality Control

Batch: S249901 DMSO] 68 mg/mL] false] Ethanol] 68 mg/mL] false] Water] 17 mg/mL] false Purity: 99.06%

99.06

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Biological Activity

Description

Phenoxybenzamine HCl (NSC 37448, NCI-c01661) is a non-specific, irreversible alpha antagonist with an IC50 of 550 nM.

Targets

α-adrenergic receptor ^[1]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT01379898	Completed	Pheochromocytoma	University Medical Center Groningen\|Radboud University Medical Center\|UMC Utrecht\|VU University of Amsterdam\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|Leiden University Medical Center\|Erasmus Medical Center\|Maastricht University Medical Center\|St. Antonius Hospital\|Medisch Spectrum Twente\|Maxima Medical Center\|Canisius-Wilhelmina Hospital\|Onze Lieve Vrouwe Gasthuis\|Atrium Medical Center\|Isala	December 2011	Phase 4
NCT00770705	Withdrawn	Congenital Heart Disease	Vanderbilt University\|Vanderbilt University Medical Center	October 2008	Phase 2

Chemical lnformation & Solubility

Molecular Weight	340.3	Formula	C₁₈H₂₂ClNO.HCl
CAS No.	63-92-3	SDF	Download Phenoxybenzamine HCl SDF
Smiles	CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 68 mg/mL ( (199.82 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 68 mg/mL

Water : 17 mg/mL

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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