Home Neuronal Signaling Dopamine Receptor agonist Pramipexole For research use only.

Pramipexole

Synonyms: SND 919,Mirapexin,Sifrol,Mirapex

Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.

Pramipexole Chemical Structure

Pramipexole Chemical Structure

CAS: 104632-26-0

Selleck's Pramipexole has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.98%
99.98

Other Dopamine Receptor Products

Related compound libraries

Choose Selective Dopamine Receptor Inhibitors

Cell Data

Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
CHO cells Function assay High inhibition constant against [3H]spiperone binding to human Dopamine receptor D3 expressed in CHO cells, Ki=0.88 nM 15801839
Click to View More Cell Line Experimental Data

Biological Activity

Description Pramipexole (SND 919,Mirapexin,Sifrol,Mirapex) is a partial/full D2S, D2L, D3, D4 receptor agonist with a Ki of 3.9, 2.2, 0.5 and 5.1 nM for D2S, D2L, D3, D4 receptor, respectively.
Targets
D3 receptor [1] D2L Receptor [1] D2S Receptor [1] D4 receptor [1]
0.5 nM(Ki) 2.2 nM(Ki) 3.9 nM(Ki) 5.1 nM(Ki)
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03683225 Active not recruiting Idiopathic Parkinson Disease Chase Therapeutics Corporation April 1 2019 Phase 2
NCT03642964 Active not recruiting Major Depressive Disorder (MDD) Chase Therapeutics Corporation September 10 2018 Phase 2
NCT02101138 Unknown status Hypereosinophilic Syndrome National Institute of Allergy and Infectious Diseases (NIAID)|Knopp Biosciences|National Institutes of Health Clinical Center (CC) March 14 2014 Phase 2
NCT01733199 Completed Parkinson''s Disease|Secondary Behavioural Addiction Nantes University Hospital October 2012 Phase 4
NCT01607034 Completed Healthy Volunteers Knopp Biosciences June 2012 Phase 1
NCT01597310 Completed Healthy Volunteers Knopp Biosciences May 2012 Phase 1

Chemical lnformation & Solubility

Molecular Weight 211.33 Formula

C10H17N3S
CAS No. 104632-26-0 SDF Download Pramipexole SDF
Smiles CCCNC1CCC2=C(C1)SC(=N2)N
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 42 mg/mL ( (198.74 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 42 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Pramipexole | Pramipexole ic50 | Pramipexole price | Pramipexole cost | Pramipexole solubility dmso | Pramipexole purchase | Pramipexole manufacturer | Pramipexole research buy | Pramipexole order | Pramipexole mouse | Pramipexole chemical structure | Pramipexole mw | Pramipexole molecular weight | Pramipexole datasheet | Pramipexole supplier | Pramipexole in vitro | Pramipexole cell line | Pramipexole concentration | Pramipexole nmr