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Pramipexole 2HCl Monohydrate

Name: Pramipexole 2HCl Monohydrate
Brand: Selleck Chemicals
SKU: S2011
Rating: 5 (2 reviews)

Catalog No.S2011 Purity: 100%

Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

Pramipexole 2HCl Monohydrate Chemical Structure

CAS: 191217-81-9

Selleck's Pramipexole 2HCl Monohydrate has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 100%

100

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Biological Activity

Description

Pramipexole 2HCl Monohydrate is a novel non-ergoline dopamine (DA) agonist, used to treat Parkinson's disease.

Targets

D2S Receptor ^[1]

D2L Receptor ^[1]

D3 receptor ^[1]

D4 receptor ^[1]

In vitro
In vitro	Pramipexole, a chemically novel dopamine agonist used for the treatment of Parkinson's disease symptoms, possesses antioxidant activity and is neuroprotective toward substantia nigral dopamine neurons in hypoxic-ischemic and methamphetamine models. Pramipexole reduces the levels of oxygen radicals produced by methylpyridinium ion (MPP+) both when incubated with SH-SY5Y cells and when perfused into rat striatum. Pramipexole also exhibits a concentration-dependent inhibition of opening of the mitochondrial transition pore induced by calcium and phosphate or MPP+. ^[1] Pramipexole decreases the levels of dopamine metabolites dose dependently, whereas striatal dopamine levels remains unchanged. ^[2] Pramipexole acts in both of these models to reduce the elevated dopamine turnover and the associated elevation in hydroxyl radical production secondary to increased MAO activity that could be responsible for oxidative damage to the nigrostriatal neurons. ^[3] Pramipexole (4-100 mM) significantly attenuates DA- or L-DOPA-induced cytotoxicity and apoptosis, an action which is not blocked by D3 antagonist U-99194 A or D2 antagonist raclopride. Pramipexole also protects MES 23.5 cells from hydrogen peroxide-induced cytotoxicity in a dose-dependent manner. Pramipexole can effectively inhibit the formation of melanin, an end product resulting from DA or L-DOPA oxidation in cell-free system. ^[4]

In Vivo
In vivo	Pramipexole (0.001-1 mg/kg s.c.) reduces exploratory locomotor activity in mice. ^[2] Pramipexole (1 mg/kg, p.o.) is able to significantly reduce the increased DA turnover, but by only 16%. ^[3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03683225	Active not recruiting	Idiopathic Parkinson Disease	Chase Therapeutics Corporation	April 1 2019	Phase 2
NCT03642964	Active not recruiting	Major Depressive Disorder (MDD)	Chase Therapeutics Corporation	September 10 2018	Phase 2
NCT02101138	Unknown status	Hypereosinophilic Syndrome	National Institute of Allergy and Infectious Diseases (NIAID)\|Knopp Biosciences\|National Institutes of Health Clinical Center (CC)	March 14 2014	Phase 2
NCT01733199	Completed	Parkinson''s Disease\|Secondary Behavioural Addiction	Nantes University Hospital	October 2012	Phase 4
NCT01607034	Completed	Healthy Volunteers	Knopp Biosciences	June 2012	Phase 1
NCT01597310	Completed	Healthy Volunteers	Knopp Biosciences	May 2012	Phase 1

References

[4] Zou L, et al. Life Sci, 1999, 64(15), 1275-1285.

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Chemical lnformation & Solubility

Molecular Weight	302.26	Formula	C₁₀H₁₇N₃S.2HCl.H₂O
CAS No.	191217-81-9	SDF	Download Pramipexole 2HCl Monohydrate SDF
Smiles	CCCNC1CCC2=C(C1)SC(=N2)N.O.Cl.Cl
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

Water : 60 mg/mL

DMSO : 41 mg/mL ( (135.64 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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