Home Neuronal Signaling P2 Receptor antagonist Prasugrel For research use only.

Prasugrel

Synonyms: Effient, Efient, Prasita,CS-747, LY640315,PCR 4099

Prasugrel (Effient, Efient, Prasita,CS-747, LY640315,PCR 4099) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.

Prasugrel Chemical Structure

Prasugrel Chemical Structure

CAS: 150322-43-3

Selleck's Prasugrel has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Prasugrel (Effient, Efient, Prasita,CS-747, LY640315,PCR 4099) is a thienopyridine ADP receptor (P2Y12) antagonist, used for the reduction of thrombotic cardiovascular events.
Targets
P2Y12 receptor [1]
In vitro
In vitro

Prasugrel is a novel orally active thienopyridine with faster, higher and more reliable inhibition of platelet aggregation than clopidogrel reflecting its metabolism in vivo to an active metabolite with selective P2Y(12) antagonistic activity. [1]
Experimental Result Images Methods Biomarkers Images PMID
Western blot p-VEGDFR2 / VEGFR2 / p-STAT3 / STAT3 / p-p65 / p65 / p-AKT / AKT / p-ERK / ERK 28383032
In Vivo
In vivo

Prasugrel shows platelet inhibition that was 8.2 times more potent than clopidogrel in WT mice. [1] Prasugrel (3 and 10 mg/kg) dose-relatedly and significantly reduces thrombus-mediated cerebral infarction 24 hours after the irradiation in rat models of cerebral and peripheral arterial occlusive diseases. Prasugrel (0.3-3 mg/kg) reduces incidence, total area, and total number of cerebral infarcts in a dose-related manner 24 hours after the vascular injury in an embolic infarction rats model. Prasugrel (0.03-3 mg/kg/day) administered from the day before the lauric acid injection for 11 successive days inhibits the progression of the disease in a dose-related manner in rats with lauric acid-induced peripheral arterial occlusive diseases. [2] Prasugrel administrated in dogs (0.03-0.3 mg/kg/day) and monkeys (0.1 and 0.3 mg/kg/day) once a day for 14 days results in potent, dose-related and cumulative inhibition of ADP-induced platelet aggregation. Prasugrel (0.1-1 mg/kg/day, p.o.) significantly prolongs the time to arterial occlusion and increases the duration of arterial patency in a rat model of electrically-induced arterial thrombosis. [3]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05774431 Recruiting Acute Myocardial Infarction University Hospital Heidelberg|AstraZeneca March 13 2023 --
NCT05053828 Completed Type2 Diabetes|Antiplatelet Drugs|Myocardial Infarction|Heart Failure Tabula Rasa HealthCare September 20 2021 --
NCT04471870 Completed Acute Coronary Syndrome Chiesi Farmaceutici S.p.A. October 23 2020 --

Chemical lnformation & Solubility

Molecular Weight 373.44 Formula

C20H20FNO3S
CAS No. 150322-43-3 SDF Download Prasugrel SDF
Smiles CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3F)C(=O)C4CC4
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 33 mg/mL ( (88.36 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
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