Home Neuronal Signaling P2 Receptor modulator Clopidogrel (SR-25990C) Bisulfate For research use only.

Clopidogrel (SR-25990C) Bisulfate

Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent.

Clopidogrel (SR-25990C) Bisulfate Chemical Structure

Clopidogrel (SR-25990C) Bisulfate Chemical Structure

CAS: 120202-66-6

Selleck's Clopidogrel (SR-25990C) Bisulfate has been cited by 8 Publications

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Purity & Quality Control

Batch: Purity: 99.98%
99.98

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Biological Activity

Description Clopidogrel (SR-25990C) Bisulfate is an oral, thienopyridine class antiplatelet agent.
Targets
P2Y12 [1]
In vitro
In vitro Clopidogrel is converted to its active metabolite by cytochrome P450 (CYP) enzymes. [1] Clopidogrel (1 μM) also inhibits EGF-stimulated EGF receptor, PERK expression, and cell proliferation in RGM-1 cells (P<0.05), and causes much less inhibition of EGF-stimulated cell proliferation in EGF receptor over-expressed RGM-1 cells than in RGM-1 cells (22% vs. 32% reduction). [2] Clopidogrel increases blood vessel number, reduces polymorphonuclear count and decreases attachment and bone loss, also decreases osteoclast number in rats submitted or not to periodontal repair. Clopidogrel decreases CXCL4, CXCL12 and PDGF content compared with saline-treated rats, without affecting CXCL5. [3]
Experimental Result Images Methods Biomarkers Images PMID
Western blot ATF2 / ATF3 / ATF4 / ATF6 TRIB3 / CHOP 24058556
In Vivo
In vivo Clopidogrel (2mg and 10mg/kg/day) significantly decreases ulcer-induced gastric epithelial cell proliferation and ulcer-stimulated expressions of EGF receptor and phosphorylated extracellular signal-regulated kinase (PERK) at the ulcer margin of rats. [2] Clopidogrel improves endothelial function and NO bioavailability in rats with congestive heart failure. Clopidogrel-treated Congestive heart failure (CHF) rat displays enhances phosphorylation of AKT and eNOS. [4] The clopidogrel/aspirin combination shows only additive-type effects on bleeding time prolongation induced by ear transection in the rabbit, therefore showing that combined inhibition of cyclooxygenase and ADP's effects provide a marked enhanced antithrombotic efficacy. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05723926 Not yet recruiting Atrial Fibrillation|Oral Anticoagulation|Stroke|Implant Javelin Medical|Population Health Research Institute January 20 2025 Not Applicable
NCT06047002 Recruiting Peripheral Arterial Disease University of Leicester September 29 2022 --
NCT05166538 Unknown status Multi Vessel Coronary Artery Disease Yonsei University February 1 2022 Phase 4
NCT05162053 Completed Acute Coronary Syndrome Jiangsu vcare pharmaceutical technology co. LTD December 9 2021 Phase 1
NCT05122455 Recruiting SCAD|AMI University of Sao Paulo|Daiichi Sankyo Inc. September 14 2021 Phase 2|Phase 3

Chemical lnformation & Solubility

Molecular Weight 419.9 Formula

C16H16ClNO2S.H2SO4
CAS No. 120202-66-6 SDF Download Clopidogrel (SR-25990C) Bisulfate SDF
Smiles COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3.OS(=O)(=O)O
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 83 mg/mL ( (197.66 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 83 mg/mL

Water : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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