Home Neuronal Signaling P2 Receptor inhibitor Ticlopidine HCl For research use only.

Ticlopidine HCl

Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.

Ticlopidine HCl Chemical Structure

Ticlopidine HCl Chemical Structure

CAS: 53885-35-1

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Ticlopidine HCl is an P2 receptor inhibitor against ADP-induced platelet aggregation with IC50 of ~2 μM.
Targets
P2 receptor [1]
~2 μM
In vitro
In vitro Ticlopidine HCl is an antiplatelet drug in the thienopyridine family. Ticlopidine HCl inhibits platelet aggregation by altering the function of platelet membranes by blocking ADP receptors. This prevents the conformational change of glycoprotein IIb/IIIa which allows platelet binding to fibrinogen. [1] Ticlopidine HCl inhibits platelet aggregation and prostaglandin synthesis from endogenous substrate through activating basal and PGE1-stimulated activity of the cyclase, preventing PGE2-induced depression of the cyclase activity and thus increasing platelet c-AMP level. [2]
In Vivo
In vivo Ticlopidine HCl inhibits platelet aggregation with IC50 of ~2 μM in men. [1] Ticlopidine HCl, when orally administered to rats, results in activation of basal and prostaglandin E1 (PGE1)-stimulated adenylate cylase activity through increase in affinity of the cyclase in platelet membrane to PGE1, although it failed to affect adenosine- or sodium fluoride-stimulated activity of the enzyme. [2]

Chemical lnformation & Solubility

Molecular Weight 300.25 Formula

C14H14ClNS.HCl
CAS No. 53885-35-1 SDF Download Ticlopidine HCl SDF
Smiles C1CN(CC2=C1SC=C2)CC3=CC=CC=C3Cl.Cl
Storage (From the date of receipt)

In vitro
Batch:

Water : 60 mg/mL

DMSO : 22 mg/mL ( (73.27 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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