Home GPCR & G Protein Adrenergic Receptor antagonist Prazosin HCl For research use only.

Prazosin HCl

Synonyms: cp-12299-1

Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.

Prazosin HCl Chemical Structure

Prazosin HCl Chemical Structure

CAS: 19237-84-4

Selleck's Prazosin HCl has been cited by 1 publication

Purity & Quality Control

Batch: Purity: 99.99%
99.99

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Biological Activity

Description Prazosin HCl (cp-12299-1) is a competitive alpha-1 adrenoceptor antagonist, used to treat high blood pressure or benign prostatic hyperplasia.
Targets
alpha-adrenergic receptor [1]
In vitro
In vitro Prazosin leads to a significant increase in VEGF concentration in endothelial cells and angiogenesis only if eNOS is present. Prazosin binds to the α1-adrenergic receptors that are present on smooth muscle cells surrounding all larger blood vessels. [1] Prazosin (0.1 nM) blocks the increases in perfusion pressure caused by electrical stimulation of the perimesenteric nerves but does not significantly reduce the vasomotor effect of exogenous noradrenaline. [2]
In Vivo
In vivo Prazosin application leads to the expansion of the capillary system by modulation of the hemodynamic environment (flow rate, shear stress) in skeletal muscle. Prazosin induces angiogenesis in extensor digitorum longus (EDL) muscles of C57BL/6 mice but not eNOS-knockout mice. [1] Prazosin (0.5-2.0 mg/kg) blocks Yohimbine-induced reinstatement of food and alcohol seeking, as well as footshock-induced reinstatement of alcohol seeking in rats. [3] Prazosin (0.2mg kg(-1) s.c.) causes an enhancement of a suppression of conditioned avoidance response in the presence of the dopamine D2 receptor antagonist raclopride (0.05-0.20 mg/kg s.c.) in rats. [4] Prazosin administration alone (1 mg/kg, s.c.) only slightly reduces horizontal activity during an initial 10 min measurement period, although it consistently reduces rearing in freely moving rats. Prazosin effectively suppresses the locomotor stimulation caused by either dose of MK-801 throughout the whole observation period in freely moving rats. [5]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05189977 Unknown status Post-traumatic Stress Disorder (PTSD) Otsuka Pharmaceutical Development & Commercialization Inc.|Iqvia Pty Ltd August 22 2022 Phase 1
NCT04365257 Terminated COVID-19 Johns Hopkins University|Fast Grants May 13 2020 Phase 2
NCT03045016 Completed Acute Stress Disorder Hospices Civils de Lyon April 21 2017 Phase 2
NCT02193256 Completed Cigarette Smoking|Alcohol Use Disorders Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA) July 2014 Early Phase 1
NCT01178138 Completed Continuous Methamphetamine Abuse University of Arkansas|National Institute on Drug Abuse (NIDA) December 2009 Phase 2

Chemical lnformation & Solubility

Molecular Weight 419.86 Formula

C19H21N5O4·HCl
CAS No. 19237-84-4 SDF Download Prazosin HCl SDF
Smiles COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 3 mg/mL ( (7.14 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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