Home NF-κB NF-κB inhibitor Sodium 4-Aminosalicylate For research use only.

Sodium 4-Aminosalicylate

Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.

Sodium 4-Aminosalicylate Chemical Structure

Sodium 4-Aminosalicylate Chemical Structure

CAS: 6018-19-5

Selleck's Sodium 4-Aminosalicylate has been cited by 2 Publications

1 Customer Review

Purity & Quality Control

Batch: S407301 DMSO] 42 mg/mL] false] Water] 42 mg/mL] false] Ethanol] Insoluble] false Purity: 99.74%
99.74

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Biological Activity

Description Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging.
Features 4-Aminosalicylate is considered to be the active moiety of sulfasalazine.
Targets
NF-κB [6]
In vitro
In vitro 4-Aminosalicylate reacts promptly with DPPH, suggesting a potent radical scavenger activity. 4-Aminosalicylate exhibits peroxyl radical scavenging activity generated by the water-soluble 2,2'-azobis-(2-amidinopropane hydrochloride) azoinitiator of peroxyl radicals, as evidenced by the inhibition of cis-parinaric acid fluorescence decay or oxygen consumption. 4-Aminosalicylate rapidly scavenges peroxyl radicals in the aqueous phase, producing a concentration-dependent inhibition period similar to Trolox or cysteine, suggesting an antioxidant activity of chain-breaking type. [1] [14C]4-Aminosalicylate transforms to a number of metabolites, among which we have characterized salicylate and gentisate, in activated mononuclear cells and activated granulocytes. 4-Aminosalicylate (0.65 mM) diminishes the lethal effect on cultured Chinese hamster ovary cells of adding either superoxide radical or hydrogen peroxide. [2] Aminosalicylate (25 mM) stimulates phospholipase D in a time- and concentration-dependent manner via a pathway involving inositol 1,4,5-trisphosphate generation, calcium fluxes, and Gi/Go in cultured mouse peritoneal macrophages. 4-aminosalicylate (20 mM) increases the levels of inositol 1,4,5-trisphosphate by 260% after treatment of macrophages. 4-aminosalicylate (5 mM) potentiates the activation of PLD by protein kinase C in cultured mouse peritoneal macrophages. [3] 4-aminosalicylate (0.1 mM) decreases the LTB4 synthesis in a dose-related fashion in isolated colonic mucosal cells, thus diminishes the LTB4/PGE2 ratio. [4] 4-aminosalicylate (0.1 mg/mL) is preferentially transported in the basolateral (BL) to apical (AP) direction, and the N-acetyl metabolite appeared only in the AP compartment. [5]
In Vivo
In vivo 4-aminosalicylate (7.5 mg/mL, regional perfusions) results in the appearance of N-acetyl-5-aminosalicylic acid in the intestinal lumen in the anesthetized rat. [5]

Chemical lnformation & Solubility

Molecular Weight 211.15 Formula

C7H7NO3.2H2O.Na
CAS No. 6018-19-5 SDF Download Sodium 4-Aminosalicylate SDF
Smiles C1=CC(=C(C=C1N)O)C(=O)[O-].O.O.[Na+]
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 42 mg/mL ( (198.91 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : 42 mg/mL

Ethanol : Insoluble


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In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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