Home Transmembrane Transporters Calcium Channel activator Chlorocresol For research use only.

Chlorocresol

Synonyms: 4-Chloro-3-methylphenol,PCMC

Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.

Chlorocresol Chemical Structure

Chlorocresol Chemical Structure

CAS: 59-50-7

Purity & Quality Control

Batch: S420901 DMSO] 29 mg/mL] false] Ethanol] 29 mg/mL] false] Water] Insoluble] false Purity: 99.62%
99.62

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Biological Activity

Description Chlorocresol(4-Chloro-3-methylphenol,PCMC) is an activator of ryanodine receptor.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Targets
ryanodine receptor [1]
In vitro
In vitro

Chlorocresol (1 mM) is capable of releasing Ca2+ from a ruthenium red/caffeine-sensitive Ca2+ release channel selectively localized in terminal cistemae (TC), whereas Chlorocresol has no effect on longitudinal sarcoplasmic reticulum (LSR), indicating that Chlorocresol is not acting by inhibiting the Ca2+-ATPase or damaging the vesicles. Chlorocresol is capable of releasing Ca2+ from heparmn-treated cerebellar microsomes. In PC12 cells, Chlorocresol releases Ca2+ from a caffeine/thapsigargin- sensitive intracellular store. The chloro and methyl groups in Chlorocresols are important for the activation of the ryanodine receptor Ca2+ release channel. [1] Chlorocresol causes muscle contracture in malignant hyperthermia-susceptible (MHS) muscles at a concentration of 25–50 mM and potentiates the caffeine contracture response in human MHS muscles. Sub-threshold (20 mM) concentrations of Chlorocresol increases both the Kd (6.0 vs. 10 mM) and the Vmax (2.2 vs. 1.55 mmol Ca2+/min/mg protein) of caffeine-induced Ca2+ release from isolated rabbit terminal cisternae. [2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05255068 Completed Alzheimer''s Disease and Related Dementias University of Iowa May 16 2022 Phase 1

Chemical lnformation & Solubility

Molecular Weight 142.58 Formula

C7H7ClO
CAS No. 59-50-7 SDF Download Chlorocresol SDF
Smiles CC1=C(C=CC(=C1)O)Cl
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 29 mg/mL ( (203.39 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 29 mg/mL

Water : Insoluble


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In vivo
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