Home Immunology & Inflammation Immunology & Inflammation related chemical Demethoxycurcumin For research use only.

Demethoxycurcumin

Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.

Demethoxycurcumin Chemical Structure

Demethoxycurcumin Chemical Structure

CAS: 22608-11-3

Purity & Quality Control

Batch: Purity: 99.04%
99.04

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Biological Activity

Description Demethoxycurcumin, a natural demethoxy derivative of curcumin, has anti-oxidant, anti-inflammatory, anti-cancer, and anti-angiogenesis properties.
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04896164 Recruiting Oral Mucositis (Ulcerative) Tata Memorial Centre December 16 2018 Phase 3
NCT01982734 Completed Pharmacokinetics of New Curcumin Formulations|Safety of New Curcumin Formulations University of Hohenheim|German Federal Ministry of Education and Research November 2012 Early Phase 1
NCT01925287 Completed Pharmacokinetics of Novel Curcumin Formulations|Safety of Novel Curcumin Formulations University of Hohenheim|German Federal Ministry of Education and Research October 2011 Early Phase 1
NCT04870060 Completed Oral Mucositis (Ulcerative) Tata Memorial Centre October 6 2010 Phase 2

Chemical lnformation & Solubility

Molecular Weight 338.35 Formula

C20H18O5
CAS No. 22608-11-3 SDF --
Smiles COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 68 mg/mL ( (200.97 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 8 mg/mL

Water : Insoluble


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In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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