Home Angiogenesis HIF inhibitor Desidustat For research use only.

Desidustat

Synonyms: ZYAN1, ZYAN1-1001

Desidustat (ZYAN1, ZYAN1-1001), an antianaemic drug candidate, is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis.

Desidustat Chemical Structure

Desidustat Chemical Structure

CAS: 1616690-16-4

Purity & Quality Control

Batch: Purity: 99.92%
99.92

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Biological Activity

Description Desidustat (ZYAN1, ZYAN1-1001), an antianaemic drug candidate, is an orally active hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor (HIF-PHI) that stimulates erythropoiesis.
Targets
PHD [1]
In Vivo
In vivo

In BALB/c mice, a single dose treatment of desidustat attenuates the effect of lipopolysaccharide (LPS) - or turpentine oil-induced inflammation and increased serum erythropoietin (EPO), iron, and reticulocyte count, and decreases serum hepcidin levels. In turpentine oil-induced anemia in BALB/c mice, repeated dose desidustat treatment increases hemoglobin, RBC and hematocrit in a dose related manner. In female Lewis rats, treatment with desidustat markedly reduces PGPS-induced anemia and increases hemoglobin, red blood cell (RBC) and white blood cell (WBC) count, hematocrit, serum iron and spleen iron.[2]
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04667533 Completed Anemia of Chronic Kidney Disease|Chemotherapy Effect Zydus Lifesciences Limited November 11 2020 Phase 1

Chemical lnformation & Solubility

Molecular Weight 332.31 Formula

C16H16N2O6
CAS No. 1616690-16-4 SDF --
Smiles OC(=O)CNC(=O)C1=C(O)C2=CC=CC=C2N(OCC3CC3)C1=O
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 12 mg/mL ( (36.11 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


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In vivo
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